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TH 1217

6522 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6522/5
Hydrolase Inhibitors Small Molecule
1 Image
Description: Potent dCTP pyrophosphatase 1 inhibitor

Chemical Name: 2-[4-[[5,6-Dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl]methyl]phenyl]-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione

Purity: ≥98%

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Biological Activity

Potent dCTPase pyrophosphatase 1 inhibitor (IC50 = 47 nM).

TH 1217 is not stable in aqueous solution. It is recommended that fresh samples are prepared and used immediately.

Technical Data

M.Wt:
491.09
Formula:
C20H17BCl2N4O6
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1862212-48-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Background References

  1. Discovery of the first potent and selective inhibitors of human dCTP pyrophosphatase 1.
    Llona-Minguez et al.
    J.Med.Chem., 2016;59:1140

Product Datasheets

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