TH 5427 hydrochloride

Key Product Details

Product Description

TH 5427 hydrochloride is a potent nudix hydrolase 5 (NUDT5) inhibitor (IC₅₀ = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Product Specifications for TH 5427 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TH 5427 hydrochloride

The following data is based on the product molecular weight 527.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.47 mL	47.37 mL	94.73 mL
1 mM	1.89 mL	9.47 mL	18.95 mL
2 mM	0.95 mL	4.74 mL	9.47 mL
10 mM	0.19 mL	0.95 mL	1.89 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Page Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. Nat.Commun. 2018 PMID: 29343827

Product Documents for TH 5427 hydrochloride