TH 5427 hydrochloride
Chemical Name: 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride
Biological ActivityTH 5427 hydrochloride is a potent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page et al.
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