TH 5427 hydrochloride

Catalog # Availability Size / Price Qty
6534/10
6534/50
Cat.No. 6534 - TH 5427 hydrochloride | C20H20Cl2N8O3.HCl
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Description: Potent NUDT5 inhibitor

Chemical Name: 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.

Technical Data

M.Wt:
527.79
Formula:
C20H20Cl2N8O3.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Background References

  1. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
    Page et al.
    Nat.Commun., 2018;9:250

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