TH 5427 hydrochloride New
Chemical Name: 7-[[5-(3,4-Dichlorophenyl)-1,3,4-oxadiazol-2-yl]methyl]-1,3-dimethyl-8-(piperazine-1-yl)-1H-purine-2,6-dione hydrochloride
Biological ActivityPotent nudix hydrolase 5 (NUDT5) inhibitor (IC50 = 29 nM). Displays >650-fold selectivity for NUDT5 over MTH1. Inhibits ATP synthesis, chromatin remodeling, gene expression and proliferation in progestin-treated breast cancer cells in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.
Page et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for TH 5427 hydrochloride
There are currently no reviews for this product. Be the first to review TH 5427 hydrochloride and earn rewards!
Have you used TH 5427 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image