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TH 588

Catalog #: 5334 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5334/25
5334/5
TH 588 | CAS No. 1609960-31-7 | MTH1 Inhibitors
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Description: Potent MTH1 inhibitor

Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

TH 588 is a potent MTH1 inhibitor (IC50 = 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice.

Technical Data

M.Wt:
295.17
Formula:
C13H12Cl2N4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1609960-31-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Thomas Helleday's Foundation for Medical Research and Oxcia AB.

Background References

  1. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
    Gad et al.
    Nature, 2014;508:215

Product Datasheets

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