Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine
Biological ActivityTH 588 is a potent MTH1 inhibitor (IC50 = 5 nM). Induces oxidative DNA damage and reduces survival in cancer cells. Inhibits growth of breast and colorectal cancer xenografts in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Gad et al.
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