TH 9619 disodium salt

Key Product Details

Product Description

TH 9619 disodium salt is a potent and selective methylenetetrahydrofolate dehydrogenase inhibitor (MTHFD2; IC₅₀ = 47 nM). It shows efficacity on HL-60 cell viability with EC₅₀ of 11nM. In vitro, It shows antiproliferative efficacy in acute myeloid leukemia (AML) cells and T-ALL Jurkat cells. In vivo, TH9619 disodium salt impairs cancer progression in a mouse disease model of AML.

Licensing Information

Sold under license from Thomas Helleday's Foundation for Medical Research and One-Carbon Therapeutics

Product Specifications for TH 9619 disodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TH 9619 disodium salt

The following data is based on the product molecular weight 495.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.09 mL	50.47 mL	100.94 mL
1 mM	2.02 mL	10.09 mL	20.19 mL
2 mM	1.01 mL	5.05 mL	10.09 mL
10 mM	0.20 mL	1.01 mL	2.02 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bonagas Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nat.Cancer 2022 PMID: 35228749

Product Documents for TH 9619 disodium salt