Thalidomide-4-hydroxyacetate

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Thalidomide-4-hydroxyacetate | CAS No. 1061605-21-7 | Degrader Building Blocks
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Description: Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name: 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid

Purity: ≥98%

Product Details
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Biological Activity

Thalidomide-4-hydroxyacetate is a derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

Thalidomide-4-hydroxyacetate has been recently renamed. The previous name for this product was TC E3 5031.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
332.26
Formula:
C15H12N2O7
Purity:
≥98%
Storage:
Store at RT
CAS No:
1061605-21-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development.
    Lohbeck and Miller
    Bioorg.Med.Chem.Lett., 2016;26:5260

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