Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide
Biological ActivitySelective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a primary target of Thal. teratogenicity.
Ito et al.
Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome.
Donovan et al.
Thal. reduces MPTP-induced decrease in striatal DA levels in mice.
Boireau et al.
Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.
Kanbayashi et al.
Thal. inhibits the replication of human-immunodeficiency-virus type 1.
Makonkawkeyoon et al.
Thal. influences growth and vasculogenic mimicry channel formation in melanoma.
Zhang et al.
J.Exp.Clin.Cancer Res., 2008;27:60
Thal. selectively inhibits tumor necrosis factor α production by stimulated human monocytes.
Sampaio et al.
Network bioinformatics analysis provides insight into drug repurposing for COVID-2019
Li et al.
Preprint - Paper not yet peer reviewed.., 2020;
Citations for Thalidomide
The citations listed below are publications that use Tocris products. Selected citations for Thalidomide include:
12 Citations: Showing 1 - 10
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
Authors: Prete Et al.
J Biol Chem 2016;291:17209
Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
Authors: Helmy Et al.
PLoS One 2015;10:e0142303
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
Authors: Sandur Et al.
Mol Cancer Res 2010;8:107
Intraperitoneal injection of Thal. attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model.
Authors: Gu Et al.
Mol Pain 2010;6:64
γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
Authors: Kannappan Et al.
J Biol Chem 2010;285:33520
Effect of Thal. and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.
Authors: Girgis Et al.
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
Authors: Pandey Et al.
Int J Cancer 2010;127:282
Curcumin circumvents chemoresistance in vitro and potentiates the effect of Thal. and borte. against human multiple myeloma in nude mice model.
Authors: Sung Et al.
Mol Cancer Ther 2009;8:959
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
Authors: Pathak Et al.
Mol Cancer Res 2007;5:943
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Authors: Ahn Et al.
Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw.
Authors: Rocha Et al.
Br J Pharmacol 2006;148:688
DMSO mimics inhibitory effect of Thal. on choriocapillary endothelial cell proliferation in culture.
Authors: Eter and Spitznas
Oncol Lett 2002;86:1303
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