Thalidomide

Catalog # Availability Size / Price Qty
0652/100
Thalidomide | CAS No. 50-35-1 | Cytokine Compounds
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Description: Binds cereblon; also TNF-α synthesis inhibitor

Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide

Purity: ≥99%

Product Details
Citations (12)
Supplemental Products
Reviews

Biological Activity

Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Anti-inflammatory; promotes T-cell activation. Predicted to reduce cytokine release in SARS-CoV-2 infection. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogenic and sedative-hypnotic. Promotes degradation of transcription factor SALL4.

Technical Data

M.Wt:
258.23
Formula:
C13H10N2O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
50-35-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a primary target of Thal. teratogenicity.
    Ito et al.
    Science, 2010;327:1345
  2. Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome.
    Donovan et al.
    Elife, 2018;7:e38430
  3. Thal. reduces MPTP-induced decrease in striatal DA levels in mice.
    Boireau et al.
    Neurosci.Lett., 1997;234:123
  4. Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.
    Kanbayashi et al.
    Neuroreport, 1996;7:1881
  5. Thal. inhibits the replication of human-immunodeficiency-virus type 1.
    Makonkawkeyoon et al.
    Proc.Natl.Acad.Sci.U.S.A., 1993;90:5974
  6. Thal. influences growth and vasculogenic mimicry channel formation in melanoma.
    Zhang et al.
    J.Exp.Clin.Cancer Res., 2008;27:60
  7. Thal. selectively inhibits tumor necrosis factor α production by stimulated human monocytes.
    Sampaio et al.
    J.Exp.Med., 1991;173:699
  8. Network bioinformatics analysis provides insight into drug repurposing for COVID-2019
    Li et al.
    Preprint - Paper not yet peer reviewed.., 2020;

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⚠ WARNING: This product can expose you to chemicals including Thalidomide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

Citations for Thalidomide

The citations listed below are publications that use Tocris products. Selected citations for Thalidomide include:

12 Citations: Showing 1 - 10

  1. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
    Authors: Prete Et al.
    J Biol Chem  2016;291:17209
  2. Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
    Authors: Helmy Et al.
    PLoS One  2015;10:e0142303
  3. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
    Authors: Sandur Et al.
    Mol Cancer Res  2010;8:107
  4. Intraperitoneal injection of Thal. attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model.
    Authors: Gu Et al.
    Mol Pain  2010;6:64
  5. γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
    Authors: Kannappan Et al.
    J Biol Chem  2010;285:33520
  6. Effect of Thal. and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.
    Authors: Girgis Et al.
    MBio  2010;1:663
  7. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
    Authors: Pandey Et al.
    Int J Cancer  2010;127:282
  8. Curcumin circumvents chemoresistance in vitro and potentiates the effect of Thal. and borte. against human multiple myeloma in nude mice model.
    Authors: Sung Et al.
    Mol Cancer Ther  2009;8:959
  9. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
    Authors: Pathak Et al.
    Mol Cancer Res  2007;5:943
  10. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
    Authors: Ahn Et al.
    Blood  2007;110:2286

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