Selective inhibitor of tumor necrosis factor
) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties.
13H 10N 2O 4
Soluble to 25 mM in DMSO
Store at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Kishimoto T et al.
Leucocyte Typing VI. Garland Publishing Inc. London.
Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice.
Boireau et al.
Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.
Kanbayashi et al.
Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes.
Sampaio et al.
Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma.
Zhang et al.
J.Exp.Clin.Cancer Res., 2008;27:60
Thalidomide inhibits the replication of human-immunodeficiency-virus type 1.
Makonkawkeyoon et al.
Identification of a primary target of thalidomide teratogenicity.
Ito et al.
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