Catalog Number: 0652
Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide
Biological Activity
Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties.
Technical Data
  • M.Wt:
    258.23
  • Formula:
    C13H10N2O4
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    50-35-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Thalidomide reduces MPTP-induced decrease in striatal dopamine levels in mice.
    Boireau et al.
    Neurosci.Lett., 1997;234:123
  3. Thalidomide, a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.
    Kanbayashi et al.
    Neuroreport, 1996;7:1881
  4. Thalidomide selectively inhibits tumor necrosis factor α production by stimulated human monocytes.
    Sampaio et al.
    J.Exp.Med., 1991;173:699
  5. Thalidomide influences growth and vasculogenic mimicry channel formation in melanoma.
    Zhang et al.
    J.Exp.Clin.Cancer Res., 2008;27:60
  6. Thalidomide inhibits the replication of human-immunodeficiency-virus type 1.
    Makonkawkeyoon et al.
    Proc.Natl.Acad.Sci.U.S.A., 1993;90:5974
  7. Identification of a primary target of thalidomide teratogenicity.
    Ito et al.
    Science, 2010;327:1345
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Thalidomide include:

9 Citations: Showing 1 - 9
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  1. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
    Authors: Sandur Et al.
    Mol Cancer Res 2010;8:107
  2. Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model.
    Authors: Gu Et al.
    Mol Pain 2010;6:64
  3. γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
    Authors: Kannappan Et al.
    J Biol Chem 2010;285:33520
  4. Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.
    Authors: Girgis Et al.
    MBio 2010;1:663
  5. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
    Authors: Pandey Et al.
    Int J Cancer 2010;127:282
  6. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
    Authors: Sung Et al.
    Mol Cancer Ther 2009;8:959
  7. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
    Authors: Pathak Et al.
    Mol Cancer Res 2007;5:943
  8. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
    Authors: Ahn Et al.
    Blood 2007;110:2286
  9. DMSO mimics inhibitory effect of thalidomide on choriocapillary endothelial cell proliferation in culture.
    Authors: Eter and Spitznas
    Oncol Lett 2002;86:1303

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