Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide
Biological ActivitySelective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties. Promotes degradation of transcription factor SALL4.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a primary target of Thal. teratogenicity.
Ito et al.
Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome.
Donovan et al.
Thal. reduces MPTP-induced decrease in striatal DA levels in mice.
Boireau et al.
Thal., a hypnotic with immune modulating properties, increases cataplexy in canine narcolepsy.
Kanbayashi et al.
Thal. inhibits the replication of human-immunodeficiency-virus type 1.
Makonkawkeyoon et al.
Thal. influences growth and vasculogenic mimicry channel formation in melanoma.
Zhang et al.
J.Exp.Clin.Cancer Res., 2008;27:60
Thal. selectively inhibits tumor necrosis factor α production by stimulated human monocytes.
Sampaio et al.
Citations for Thalidomide
The citations listed below are publications that use Tocris products. Selected citations for Thalidomide include:
12 Citations: Showing 1 - 10
Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration.
Authors: Prete Et al.
J Biol Chem 2016;291:17209
Additive Renoprotection by pioglit. and fenofi. against Inflammatory, Oxidative and Apoptotic Manifestations of cisp. Nephrotoxicity: Modulation by PPARs.
Authors: Helmy Et al.
PLoS One 2015;10:e0142303
5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
Authors: Sandur Et al.
Mol Cancer Res 2010;8:107
Intraperitoneal injection of Thal. attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model.
Authors: Gu Et al.
Mol Pain 2010;6:64
γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
Authors: Kannappan Et al.
J Biol Chem 2010;285:33520
Effect of Thal. and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.
Authors: Girgis Et al.
Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
Authors: Pandey Et al.
Int J Cancer 2010;127:282
Curcumin circumvents chemoresistance in vitro and potentiates the effect of Thal. and borte. against human multiple myeloma in nude mice model.
Authors: Sung Et al.
Mol Cancer Ther 2009;8:959
Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
Authors: Pathak Et al.
Mol Cancer Res 2007;5:943
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
Authors: Ahn Et al.
Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw.
Authors: Rocha Et al.
Br J Pharmacol 2006;148:688
DMSO mimics inhibitory effect of Thal. on choriocapillary endothelial cell proliferation in culture.
Authors: Eter and Spitznas
Oncol Lett 2002;86:1303
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