( 10 citations )    
Product Datasheet
Catalog Number:0652
Chemical Name:N-(2,6-dioxo-3-piperidinyl)phthalimide
Product Details
Citations (10)
Supplemental Products
Biological Activity
Selective inhibitor of tumor necrosis factor α (TNF-α) synthesis. Also binds cereblon, inhibiting ubiquitin ligase activity. Teratogen, sedative-hypnotic with inherent anti-inflammatory properties.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets

The citations listed below are publications that use Tocris products. Selected citations for Thalidomide include:

10 Citations: Showing 1 - 10
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  1. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
    Authors: Sandur Et al.
    Mol Cancer Res  2010;8:107
  2. Intraperitoneal injection of thalidomide attenuates bone cancer pain and decreases spinal tumor necrosis factor-α expression in a mouse model.
    Authors: Gu Et al.
    Mol Pain  2010;6:64
  3. γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
    Authors: Kannappan Et al.
    J Biol Chem  2010;285:33520
  4. Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line.
    Authors: Girgis Et al.
    MBio  2010;1:663
  5. Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.
    Authors: Pandey Et al.
    Int J Cancer  2010;127:282
  6. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model.
    Authors: Sung Et al.
    Mol Cancer Ther  2009;8:959
  7. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells.
    Authors: Pathak Et al.
    Mol Cancer Res  2007;5:943
  8. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products.
    Authors: Ahn Et al.
    Blood  2007;110:2286
  9. Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw.
    Authors: Rocha Et al.
    Br J Pharmacol  2006;148:688
  10. DMSO mimics inhibitory effect of thalidomide on choriocapillary endothelial cell proliferation in culture.
    Authors: Eter and Spitznas
    Oncol Lett  2002;86:1303


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