Thalidomide 4'-ether-PEG2-alkyne

Catalog # Availability Size / Price Qty
Thalidomide 4'-ether-PEG2-alkyne | CAS No. 2098487-52-4 | Degrader Building Blocks
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Description: Cereblon ligand with PEG linker and terminal alkyne for onward chemistry
Alternative Names: Thalidomide - linker 5

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione

Purity: ≥95%

Product Details

Biological Activity

Thalidomide 4'-ether-PEG2-alkyne is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG2 linker with alkyne terminal ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

This product has been recently renamed. The previous name for this product was Thalidomide - linker 5

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Degradation of the BAF complex factor BRD9 by heterobifunctional ligands.
    Remillard et al.
    Angew.Chem.Int.Ed.Engl., 2017;56:5738

Product Datasheets

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