Thalidomide 4'-oxyacetamide-alkylC4-azide

Tocris Bioscience | Catalog # 6300

Cereblon ligand with alkyl linker and terminal azide for onward chemistry
Tocris Bioscience

Key Product Details

Description

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Alternative Names

Azido-Thalidomide
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Product Description

Thalidomide 4'-oxyacetamide-alkylC4-azide is a click-activated Thalidomide (Cat.No. 0652); precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an azide functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

This product has been recently renamed. The previous name for this product was Azido-Thalidomide

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for Thalidomide 4'-oxyacetamide-alkylC4-azide

Molecular Weight

428.40

Formula

C19H20N6O6

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

CAS Number

2098488-36-7

PubChem ID

131704500

InChI Key

USWFAZSQVLTHHA-UHFFFAOYSA-N

SMILES

[N-]=[N+]=NCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Thalidomide 4'-oxyacetamide-alkylC4-azide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Thalidomide 4'-oxyacetamide-alkylC4-azide

For research use only

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