Thalidomide 4'-oxyacetamide-alkylC4-azide

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6300/50
Thalidomide 4'-oxyacetamide-alkylC4-azide | CAS No. 2098488-36-7 | Degrader Building Blocks
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Description: Cereblon ligand with alkyl linker and terminal azide for onward chemistry
Alternative Names: Azido-Thalidomide

Chemical Name: N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Purity: ≥98%

Product Details
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Biological Activity

Thalidomide 4'-oxyacetamide-alkylC4-azide is a click-activated Thalidomide (Cat.No. 0652); precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an azide functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

This product has been recently renamed. The previous name for this product was Azido-Thalidomide

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M.Wt:
428.4
Formula:
C19H20N6O6
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2098488-36-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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