Thalidomide, propargyl

Catalog # Availability Size / Price Qty
Thalidomide, propargyl | CAS No. 2098487-39-7 | Degrader Building Blocks
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Description: Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione

Product Details

Biological Activity

Click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in DMF
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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