Thalidomide, propargyl New
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione
Biological ActivityClick-activated Thalidomide (Cat.No. 0652); can be used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A "click chemistry platform" for the rapid rynthesis of bispecific molecules for inducing protein degradation.
Wurz et al.
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