Thalidomide, propargyl

Catalog # Availability Size / Price Qty
6685/50
Degrader Building Blocks Small Molecule
1 Image
Description: Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs

Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione

Purity: ≥95%

Product Details
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Biological Activity

Click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

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Technical Data

M.Wt:
312.28
Formula:
C16H12N2O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in DMF
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2098487-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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