receptor agonist (Ki
values are 59.1 and 2 nM for σ
1 and σ
2 receptors respectively) and NR2B subunit-selective NMDA receptor antagonist (IC50
values are 0.22 and 324.8 μ
M at NR2B and NR2A respectively). Displays ~8-fold reduced affinity at α
-adrenoceptors compared to Ifenprodil
(Cat.No. 0545). Inhibits the hERG potassium channel (IC50
= 88 nM) and exhibits antiarrhythmic activity in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes.
Avenet et al.
σ2-receptor ligand-mediated inhibition of inwardly rectifying K+channels in the heart.
Monassier et al.
Interactions of erythro-ifenprodil, threo-ifenprodil and erythro-iodoifenprodil, and eliprodil with subtypes of σ receptors.
Hashimoto and London
The citations listed below are publications that use Tocris products. Selected citations for threo Ifenprodil hemitartrate include:
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