threo Ifenprodil hemitartrate
Chemical Name: (1S*,2S*)-threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemitartrate
Biological Activitythreo Ifenprodil hemitartrate is a potent σ receptor agonist (Ki values are 59.1 and 2 nM for σ1 and σ2 receptors respectively) and GluN2B (formally NR2B) subunit-selective NMDA receptor antagonist (IC50 values are 0.22 and 324.8 μM at GluN2B and GluN2A respectively). Displays ~8-fold reduced affinity at α-adrenoceptors compared to Ifenprodil (Cat.No. 0545). Inhibits the hERG potassium channel (IC50 = 88 nM) and exhibits antiarrhythmic activity in vivo.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Interactions of erythro-ifenprodil, threo-ifenprodil and erythro-iodoifenprodil, and eliprodil with subtypes of σ receptors.
Hashimoto and London
Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes.
Avenet et al.
σ2-receptor ligand-mediated inhibition of inwardly rectifying K+channels in the heart.
Monassier et al.
Citations for threo Ifenprodil hemitartrate
The citations listed below are publications that use Tocris products. Selected citations for threo Ifenprodil hemitartrate include:
2 Citations: Showing 1 - 2
Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
Authors: Lassus Et al.
Sci Rep 2018;8:17461
Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.
Authors: Gasperini Et al.
Sci Rep 2015;22:772
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