threo Ifenprodil hemitartrate

Catalog # Availability Size / Price Qty
2892/10
2892/50
threo Ifenprodil hemitartrate | CAS No. 1312991-83-5 | NMDA Receptor Antagonists
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Description: GluN2B-selective NMDA antagonist; also σ agonist

Chemical Name: (1S*,2S*)-threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemitartrate

Product Details
Citations (2)
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Biological Activity

Potent σ receptor agonist (Ki values are 59.1 and 2 nM for σ1 and σ2 receptors respectively) and GluN2B (formally NR2B) subunit-selective NMDA receptor antagonist (IC50 values are 0.22 and 324.8 μM at GluN2B and GluN2A respectively). Displays ~8-fold reduced affinity at α-adrenoceptors compared to Ifenprodil (Cat.No. 0545). Inhibits the hERG potassium channel (IC50 = 88 nM) and exhibits antiarrhythmic activity in vivo.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
400.49
Formula:
C21H27NO2.½C4H6O6
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Storage:
Store at RT
CAS No:
1312991-83-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for threo Ifenprodil hemitartrate

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