Catalog Number: 2892
Chemical Name: (1S*,2S*)-threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemitartrate
Biological Activity
Potent σ receptor agonist (Ki values are 59.1 and 2 nM for σ1 and σ2 receptors respectively) and NR2B subunit-selective NMDA receptor antagonist (IC50 values are 0.22 and 324.8 μM at NR2B and NR2A respectively). Displays ~8-fold reduced affinity at α-adrenoceptors compared to Ifenprodil (Cat.No. 0545). Inhibits the hERG potassium channel (IC50 = 88 nM) and exhibits antiarrhythmic activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water and to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes.
    Avenet et al.
    Eur.J.Pharmacol., 1996;296:209
  2. σ2-receptor ligand-mediated inhibition of inwardly rectifying K+channels in the heart.
    Monassier et al.
    J.Pharmacol.Exp.Ther., 2007;322:341
  3. Interactions of erythro-ifenprodil, threo-ifenprodil and erythro-iodoifenprodil, and eliprodil with subtypes of σ receptors.
    Hashimoto and London
    Eur.J.Pharmacol., 1995;273:307

The citations listed below are publications that use Tocris products. Selected citations for threo Ifenprodil hemitartrate include:

1 Citations: Showing 1 - 1

  1. Prion protein and copper cooperatively protect neurons by modulating NMDA receptor through S-nitrosylation.
    Authors: Gasperini Et al.
    Sci Rep 2015;22:772

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