Chemical Name: (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
Biological ActivityNMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ2 ligand displaying about 3-fold selectivity over σ1 sites.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Polyamine-sensitive binding of [3H]ifenprodil, a novel NMDA antagonist to the rat cerebral cortex.
Schoemaker et al.
Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents. 1. Evidence for efficacy in models of focal cerebral ischemia.
Gotti et al.
Neuroprotective effects of the N-MthD.-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
Shalaby et al.
Ifenprodil is a novel type of N-MthD.-aspartate receptor antagonist: interaction with polyamines.
Reynolds and Miller
Citations for Ifenprodil hemitartrate
The citations listed below are publications that use Tocris products. Selected citations for Ifenprodil hemitartrate include:
32 Citations: Showing 1 - 10
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.
Authors: Regan Et al.
Nat Commun 2019;10:321
The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
Authors: McKay Et al.
Cell Rep 2018;25:841
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Authors: Grochowska Et al.
EMBO Rep 2017;18:962
Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
Authors: Kashima and Grueter
Proc Natl Acad Sci U S A. 2017;114(33):8865
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
Authors: Galvez Et al.
GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice.
Authors: Engelhardt Et al.
Proc Natl Acad Sci U S A 2015;9:95
Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
Authors: Mirante Et al.
J Neurosci 2014;7:62
Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.
Authors: Thomazeau Et al.
J Neurosci 2014;34:1138
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
Front Cell Neurosci 2014;17:1943
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Authors: Simma Et al.
Cell Commun Signal 2014;12:75
Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus.
Authors: Brady Et al.
Int J Neuropsychopharmacol 2013;33:1062
Molecular pharmacology of human NMDA receptors.
Authors: Hedegaard Et al.
Neurochem Int 2012;61:601
Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.
Authors: Gourley Et al.
J Neurosci 2012;32:2314
Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
Authors: Gaamouch Et al.
J Neurosci 2012;32:10767
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
Authors: Heinrich Et al.
Br J Pharmacol 2012;167:1003
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
Authors: McKay Et al.
Br J Pharmacol 2012;166:924
GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.
Authors: Wills Et al.
Proc Natl Acad Sci U S A 2012;109:E278
Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
Authors: Zhang and Sun
J Neurosci 2011;71:221
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
Authors: Roselli Et al.
PLoS One 2011;6:e23097
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci 2010;13:958
The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-MthD.-aspartate receptors.
Authors: Yuan Et al.
J Biol Chem 2009;284:12862
Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum.
Authors: Popp Et al.
J Neurochem 2008;106:900
Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.
Authors: Fontaine Et al.
Dev Neurobiol 2008;105:16779
Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons.
Authors: Logan Et al.
J Neurophysiol 2007;98:2693
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
Authors: Ge Et al.
ERK activation causes epilepsy by stimulating NMDA receptor activity.
Authors: Nateri Et al.
EMBO J 2007;26:4891
Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function.
Authors: Kopp Et al.
J Neurosci 2006;26:12456
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.
Authors: Amadoro Et al.
Proc Natl Acad Sci U S A 2006;103:2892
Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Authors: Yang Et al.
PLoS One 2005;25:4288
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
Authors: Shin Et al.
Br J Pharmacol 2005;144:908
Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.
Authors: Ning Et al.
J Neurosci 2004;24:4052
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