Chemical Name: (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
Biological ActivityIfenprodil hemitartrate is a NMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ2 ligand displaying about 3-fold selectivity over σ1 sites.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Polyamine-sensitive binding of [3H]ifenprodil, a novel NMDA antagonist to the rat cerebral cortex.
Schoemaker et al.
Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents. 1. Evidence for efficacy in models of focal cerebral ischemia.
Gotti et al.
Neuroprotective effects of the N-MthD.-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
Shalaby et al.
Ifenprodil is a novel type of N-MthD.-aspartate receptor antagonist: interaction with polyamines.
Reynolds and Miller
Citations for Ifenprodil hemitartrate
The citations listed below are publications that use Tocris products. Selected citations for Ifenprodil hemitartrate include:
32 Citations: Showing 1 - 10
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors.
Authors: Regan Et al.
Nat Commun 2019;10:321
The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences.
Authors: McKay Et al.
Cell Rep 2018;25:841
Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.
Authors: Grochowska Et al.
EMBO Rep 2017;18:962
Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
Authors: Kashima and Grueter
Proc Natl Acad Sci U S A. 2017;114(33):8865
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
Authors: Galvez Et al.
GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice.
Authors: Engelhardt Et al.
Proc Natl Acad Sci U S A 2015;9:95
Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
Authors: Mirante Et al.
J Neurosci 2014;7:62
Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.
Authors: Thomazeau Et al.
J Neurosci 2014;34:1138
The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
Front Cell Neurosci 2014;17:1943
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Authors: Simma Et al.
Cell Commun Signal 2014;12:75
Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus.
Authors: Brady Et al.
Int J Neuropsychopharmacol 2013;33:1062
Molecular pharmacology of human NMDA receptors.
Authors: Hedegaard Et al.
Neurochem Int 2012;61:601
Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.
Authors: Gourley Et al.
J Neurosci 2012;32:2314
Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
Authors: Gaamouch Et al.
J Neurosci 2012;32:10767
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
Authors: Heinrich Et al.
Br J Pharmacol 2012;167:1003
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
Authors: McKay Et al.
Br J Pharmacol 2012;166:924
GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.
Authors: Wills Et al.
Proc Natl Acad Sci U S A 2012;109:E278
Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
Authors: Zhang and Sun
J Neurosci 2011;71:221
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
Authors: Roselli Et al.
PLoS One 2011;6:e23097
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci 2010;13:958
The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-MthD.-aspartate receptors.
Authors: Yuan Et al.
J Biol Chem 2009;284:12862
Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum.
Authors: Popp Et al.
J Neurochem 2008;106:900
Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.
Authors: Fontaine Et al.
Dev Neurobiol 2008;105:16779
Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons.
Authors: Logan Et al.
J Neurophysiol 2007;98:2693
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
Authors: Ge Et al.
ERK activation causes epilepsy by stimulating NMDA receptor activity.
Authors: Nateri Et al.
EMBO J 2007;26:4891
Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function.
Authors: Kopp Et al.
J Neurosci 2006;26:12456
NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.
Authors: Amadoro Et al.
Proc Natl Acad Sci U S A 2006;103:2892
Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
Authors: Yang Et al.
PLoS One 2005;25:4288
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
Authors: Shin Et al.
Br J Pharmacol 2005;144:908
Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.
Authors: Ning Et al.
J Neurosci 2004;24:4052
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