Ifenprodil hemitartrate

  ( 28 citations )    
Product Datasheet
Catalog Number:0545
Chemical Name:(1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
Product Details
Citations (28)
Reviews
Biological Activity
NMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ2 ligand displaying about 3-fold selectivity over σ1 sites.
Technical Data
  • M.Wt:
    400.49
  • Formula:
    C21H27NO2.½C4H6O6
  • Solubility:
    Soluble to 15 mM in water with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    23210-56-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ifenprodil hemitartrate include:

28 Citations: Showing 1 - 10
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  1. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
    Authors: Kashima and Grueter
    Proc Natl Acad Sci U S A.  2017;114(33):8865
  2. Activation of α7 nicotinic acetylcholine receptors protects potentiated synapses from depotentiation during theta pattern stimulation in the hippocampal CA1 region of rats.
    Authors: Galvez Et al.
    Neuropharmacology  2016;105:378
  3. GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice.
    Authors: Engelhardt Et al.
    Proc Natl Acad Sci U S A  2015;9:95
  4. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    J Neurosci  2014;7:62
  5. Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.
    Authors: Thomazeau Et al.
    J Neurosci  2014;34:1138
  6. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Front Cell Neurosci  2014;17:1943
  7. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Cell Commun Signal  2014;12:75
  8. Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus.
    Authors: Brady Et al.
    Int J Neuropsychopharmacol  2013;33:1062
  9. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int  2012;61:601
  10. Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.
    Authors: Gourley Et al.
    J Neurosci  2012;32:2314
  11. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci  2012;32:10767
  12. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
    Authors: Heinrich Et al.
    Br J Pharmacol  2012;167:1003
  13. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist.
    Authors: McKay Et al.
    Br J Pharmacol  2012;166:924
  14. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.
    Authors: Wills Et al.
    Proc Natl Acad Sci U S A  2012;109:E278
  15. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
    Authors: Zhang and Sun
    J Neurosci  2011;71:221
  16. CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton.
    Authors: Roselli Et al.
    PLoS One  2011;6:e23097
  17. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  18. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.
    Authors: Yuan Et al.
    J Biol Chem  2009;284:12862
  19. Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum.
    Authors: Popp Et al.
    J Neurochem  2008;106:900
  20. Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.
    Authors: Fontaine Et al.
    Dev Neurobiol  2008;105:16779
  21. Long-lasting NMDA receptor-mediated EPSCs in mouse striatal medium spiny neurons.
    Authors: Logan Et al.
    J Neurophysiol  2007;98:2693
  22. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
    Authors: Ge Et al.
    Neuron  2007;54:559
  23. ERK activation causes epilepsy by stimulating NMDA receptor activity.
    Authors: Nateri Et al.
    EMBO J  2007;26:4891
  24. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function.
    Authors: Kopp Et al.
    J Neurosci  2006;26:12456
  25. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.
    Authors: Amadoro Et al.
    Proc Natl Acad Sci U S A  2006;103:2892
  26. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    PLoS One  2005;25:4288
  27. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
    Authors: Shin Et al.
    Br J Pharmacol  2005;144:908
  28. Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.
    Authors: Ning Et al.
    J Neurosci  2004;24:4052
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