Catalog Number: 0545
Chemical Name: (1R*,2S*)-erythro-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol hemi-(DL)-tartrate
Biological Activity
NMDA receptor antagonist, acting at the polyamine site. Also an α-adrenergic vasodilator. σ2 ligand displaying about 3-fold selectivity over σ1 sites.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 15 mM in water with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ifenprodil and SL-82,0715 as cerebral anti-ischemic agents. 1. Evidence for efficacy in models of focal cerebral ischemia.
    Gotti et al.
    J.Pharmacol.Exp.Ther., 1988;247:1211
  2. Polyamine-sensitive binding of [3H]ifenprodil, a novel NMDA antagonist to the rat cerebral cortex.
    Schoemaker et al.
    Eur.J.Pharmacol., 1990;176:249
  3. Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
    Shalaby et al.
    J.Pharmacol.Exp.Ther., 1992;260:925
  4. Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines.
    Reynolds and Miller
    Mol.Pharmacol., 1989;36:758

The citations listed below are publications that use Tocris products. Selected citations for Ifenprodil hemitartrate include:

24 Citations: Showing 1 - 10
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  1. Toll-like receptor 4 deficiency alters nucleus accumbens synaptic physiology and drug reward behavior.
    Authors: Kashima and Grueter
    Proc Natl Acad Sci U S A. 2017;114(33):8865
  2. GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice.
    Authors: Engelhardt Et al.
    Proc Natl Acad Sci U S A 2015;9:95
  3. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    J Neurosci 2014;7:62
  4. Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.
    Authors: Thomazeau Et al.
    J Neurosci 2014;34:1138
  5. The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
    Authors: Sánchez-Blázquez Et al.
    Front Cell Neurosci 2014;17:1943
  6. NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
    Authors: Simma Et al.
    Cell Commun Signal 2014;12:75
  7. Moderate prenatal alcohol exposure reduces plasticity and alters NMDA receptor subunit composition in the dentate gyrus.
    Authors: Brady Et al.
    Int J Neuropsychopharmacol 2013;33:1062
  8. Molecular pharmacology of human NMDA receptors.
    Authors: Hedegaard Et al.
    Neurochem Int 2012;61:601
  9. Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.
    Authors: Gourley Et al.
    J Neurosci 2012;32:2314
  10. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci 2012;32:10767
  11. K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study.
    Authors: Heinrich Et al.
    Br J Pharmacol 2012;167:1003
  12. GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.
    Authors: Wills Et al.
    Proc Natl Acad Sci U S A 2012;109:E278
  13. Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons.
    Authors: Zhang and Sun
    J Neurosci 2011;71:221
  14. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci 2010;13:958
  15. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors.
    Authors: Yuan Et al.
    J Biol Chem 2009;284:12862
  16. Cerebellar granule cells cultured from adolescent rats express functional NMDA receptors: an in vitro model for studying the developing cerebellum.
    Authors: Popp Et al.
    J Neurochem 2008;106:900
  17. Vulnerability of white matter towards antenatal hypoxia is linked to a species-dependent regulation of glutamate receptor subunits.
    Authors: Fontaine Et al.
    Dev Neurobiol 2008;105:16779
  18. A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain.
    Authors: Ge Et al.
    Neuron 2007;54:559
  19. ERK activation causes epilepsy by stimulating NMDA receptor activity.
    Authors: Nateri Et al.
    EMBO J 2007;26:4891
  20. Insufficient sleep reversibly alters bidirectional synaptic plasticity and NMDA receptor function.
    Authors: Kopp Et al.
    J Neurosci 2006;26:12456
  21. NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.
    Authors: Amadoro Et al.
    Proc Natl Acad Sci U S A 2006;103:2892
  22. Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake.
    Authors: Yang Et al.
    PLoS One 2005;25:4288
  23. The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
    Authors: Shin Et al.
    Br J Pharmacol 2005;144:908
  24. Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.
    Authors: Ning Et al.
    J Neurosci 2004;24:4052
Expand to show all 24 Citations

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