Ticagrelor

Key Product Details

Product Description

Ticagrelor is a high affinity and reversible P2Y₁₂ antagonist (pK_i = 8.7) that displays inverse agonism in 1321N1 cells. Also high affinity inhibitor of equilibrative nucleoside transporter 1 (ENT1; K_i = 41 nM). Inhibits ADP-induced platelet aggregation.

Product Specifications for Ticagrelor

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ticagrelor

The following data is based on the product molecular weight 522.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.91 mL	9.57 mL	19.14 mL
5 mM	0.38 mL	1.91 mL	3.83 mL
10 mM	0.19 mL	0.96 mL	1.91 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Aungraheeta Inverse agonism at the P2Y₁₂ receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016 PMID: 27694321
• Armstrong Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1. J.Cardiovasc.Pharmacol.Ther. 2014 PMID: 24414167
• Springthorpe From ATP to AZD6140: the discovery of an orally active reversible P2Y₁₂ receptor antagonist for the prevention of thrombosis. Bioorg.Med.Chem.Letts. 2007 PMID: 17827008

Product Documents for Ticagrelor