Recombinant Human TIMP-2 His Protein

Novus Biologicals | Catalog # NBP2-22869

Novus Biologicals
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Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE
View all TIMP-2 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 27-220 of Human TIMP-2

Source: E.coli

Amino Acid Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCS CSPVHPQQAF CNADVVIRAK AVSEKEVDSG NDIYGNPIKR IQYEIKQIKM FKGPEKDIEF IYTAPSSAVC GVSLDVGGKK EYLIAGKAEG DGKMHITLCD FIVPWDTLST TQKKSLNHRY QMGCECKITR CPMIPCYISS PDECLWMDWV TEKNINGHQA KFFACIKRSD GSCAWYRGAA PPKQEFLDIE DP

Purity

>85%, by SDS-PAGE

Predicted Molecular Mass

26.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human TIMP-2 His Protein

SDS-PAGE: Recombinant Human TIMP-2 His Protein [NBP2-22869]

SDS-PAGE: Recombinant Human TIMP-2 His Protein [NBP2-22869]

SDS-Page: Recombinant Human TIMP-2 Protein [NBP2-22869]

Formulation, Preparation, and Storage

NBP2-22869
Formulation 20 mM Tris-HCl buffer (pH 8.0), 0.15 M NaCl, 10% glycerol, 1 mM DTT
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TIMP-2

TIMP2 is a natural inhibitor of the matrix metalloproteinases, a group of peptidases involved in of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, this protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, TIMP2 may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular. Recombinant human TIMP2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Long Name

Tissue Inhibitors of Metalloproteinases 2

Alternate Names

TIMP2

Gene Symbol

TIMP2

Additional TIMP-2 Products

Product Documents for Recombinant Human TIMP-2 His Protein

Certificate of Analysis

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Product Specific Notices for Recombinant Human TIMP-2 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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