TIRAP Antibody (20D1055.1)

Novus Biologicals | Catalog # NB100-56730

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgM Kappa Clone # 20D1055.1
View all TIRAP Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against a synthetic peptide corresponding to a portion of human TIRAP.

Clonality

Monoclonal

Host

Mouse

Isotype

IgM Kappa

Scientific Data Images for TIRAP Antibody (20D1055.1)

Western Blot: TIRAP Antibody (20D1055.1) [NB100-56730]

Western Blot: TIRAP Antibody (20D1055.1) [NB100-56730]

Western Blot: TIRAP Antibody (20D1055.1) [NB100-56730] - Analysis of TIRAP in human spleen lysate using this antibody.

Applications for TIRAP Antibody (20D1055.1)

Application
Recommended Usage

Western Blot

1:500-1:1000
Application Notes
In HUVEC, a 32 kDa band is observed.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Ascites with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TIRAP

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production (4). It has 235 amino acids and is commonly seen as a 32-37 kD protein (4).

Alternate Names

adapter protein wyatt, Adaptor protein Wyatt, MAL, MyD88 adapter-like protein, MyD88-2, TIR domain-containing adapter protein, toll/interleukin-1 receptor domain-containing adapter protein, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein, Toll-like receptor adaptor protein, wyatt

Entrez Gene IDs

114609 (Human)

Gene Symbol

TIRAP

UniProt

P58753 (Human)

Additional TIRAP Products

Product Documents for TIRAP Antibody (20D1055.1)

Certificate of Analysis

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Product Specific Notices for TIRAP Antibody (20D1055.1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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