Tizanidine hydrochloride

Key Product Details

Product Description

Tizanidine hydrochloride is an α₂-adrenergic receptor agonist. Antinociceptive upon epidural administration in rats (IC₅₀ = 48 nM). Also binds to imidazoline receptor.

Product Specifications for Tizanidine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tizanidine hydrochloride

The following data is based on the product molecular weight 290.17.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.45 mL	17.23 mL	34.46 mL
5 mM	0.69 mL	3.45 mL	6.89 mL
10 mM	0.34 mL	1.72 mL	3.45 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Piletz Autoradiographic comparison of [³H]-Clonidine binding to non-adrenergic sites and α₂-adrenergic receptors in human brain. Neuropsychopharmacology 2000 PMID: 11063925
• Asano Antinociception by epidural and systemic α₂-adrenoceptor agonists and their binding affinity in rat spinal cord and brain. Anesth.Analg. 2000 PMID: 10648329

Product Documents for Tizanidine hydrochloride