TL 13-12

Tocris Bioscience | Catalog # 6744

Selective ALK Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Selective ALK Degrader (PROTAC®)
View all Active Degraders »

Product Description

TL 13-12 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 180 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302), conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Exhibits higher selectivity for ALK over Aurora A kinase compared with TL 13 -112 (Cat. No. 6745). Maximum degradation is exhibited at 16 h.

Negative control TL 13-22 (Cat. No. 6747) and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from Dana-Farber Cancer Institute

Product Specifications for TL 13-12

Molecular Weight

961.48

Formula

C45H53ClN10O10S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

CAS Number

2229037-04-9

PubChem ID

138108740

InChI Key

WXNUIPVZMJMPNM-UHFFFAOYSA-N

SMILES

COC1=C(C=CC(N2CCN(CC2)CCOCCOCCNC(CNC3=C4C(N(C(C4=CC=C3)=O)C5CCC(NC5=O)=O)=O)=O)=C1)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 96.15 100

Preparing Stock Solutions for TL 13-12

The following data is based on the product molecular weight 961.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.04 mL 5.20 mL 10.40 mL
5 mM 0.21 mL 1.04 mL 2.08 mL
10 mM 0.10 mL 0.52 mL 1.04 mL
50 mM 0.02 mL 0.10 mL 0.21 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for TL 13-12

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TL 13-12

For research use only

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