Pomalidomide

Catalog # Availability Size / Price Qty
6302/10
6302/50
Pomalidomide | CAS No. 19171-19-8 | Ubiquitin Ligase (E3) Inhibitors
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Description: Cereblon binder; also TNF-α inhibitor and antiangiogenic

Chemical Name: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Purity: ≥98%

Product Details
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Biological Activity

Potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic. Promotes degradation of transcription factor SALL4.

Technical Data

M.Wt:
273.24
Formula:
C13H11N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
19171-19-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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