Pomalidomide

Key Product Details

Product Description

Pomalidomide is a potent TNF-α inhibitor (IC₅₀ = 13 nM). Also potently inhibits IL-2 (EC₅₀ = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic. Promotes degradation of transcription factor SALL4.

Product Specifications for Pomalidomide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Pomalidomide

The following data is based on the product molecular weight 273.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.66 mL	18.30 mL	36.60 mL
5 mM	0.73 mL	3.66 mL	7.32 mL
10 mM	0.37 mL	1.83 mL	3.66 mL
50 mM	0.07 mL	0.37 mL	0.73 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Chamberlain Evolution of cereblon-mediated protein degradation as a therapeutic modality. ACS Med.Chem.Lett. 2019 PMID: 31857833
• Donovan Thal. promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome. Elife 2018 PMID: 30067223
• Winter Phthalimide conjugation as a strategy for in vivo target protein degradation. Science. 2015 PMID: 25999370
• Lai Modular PROTAC design for the degradation of oncogenic BCR-ABL. Angew.Chem.Int.Ed.Engl. 2016 PMID: 26593377
• Nanthakumar Dissecting fibrosis: therapeutic insights from the small-molecule toolbox. Nat.Rev.Drug.Discov. 2015 PMID: 26338155
• Lohbeck & Miller Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 2016 PMID: 27687673

Product Documents for Pomalidomide