Potent TNF-α inhibitor (IC50
= 13 nM). Also potently inhibits IL-2 (EC50
= 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development.
Lohbeck & Miller
Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.
Nanthakumar et al.
Modular PROTAC design for the degradation of oncogenic BCR-ABL.
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Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter et al.