Potent TNFα inhibitor (IC50
= 13 nM). Also potently inhibits IL-2 (EC50
= 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic.
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All Tocris products are intended for laboratory research use only.
Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development.
Lohbeck & Miller
Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.
Nanthakumar et al.
Modular PROTAC design for the degradation of oncogenic BCR-ABL.
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Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter et al.