Catalog Number: 6302
Chemical Name: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Biological Activity
Potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic.
Technical Data
  • M.Wt:
    273.24
  • Formula:
    C13H11N3O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    19171-19-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development.
    Lohbeck & Miller
    Bioorg.Med.Chem.Lett., 2016;26:5260
  2. Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.
    Nanthakumar et al.
    Nat.Rev.Drug.Discov., 2015;14:693
  3. Modular PROTAC design for the degradation of oncogenic BCR-ABL.
    Lai et al.
    Angew.Chem.Int.Ed.Engl., 2016;55:807
  4. Phthalimide conjugation as a strategy for in vivo target protein degradation.
    Winter et al.
    Science., 2015;348:1376
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