Chemical Name: 5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt
Biological ActivityTM 5441 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 3.58 - 60.3 μM). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.
Eren M, Boe A, Murphy S, Place A, Nagpal V, Morales-Nebreda L, Urich D, Quaggin S, Budinger G, Mutlu G, Miyata T, Vaughan D
Proc Natl Acad Sci U S A, 2014;111(19):7090-5.
Small molecule inhibitors of plasminogen activator inhibitor-1 elicit anti-tumorigenic and anti-angiogenic activity.
Placencio et al.
PLoS One., 2015;10
Novel plasminogen activator inhibitor-1 inhibitors prevent diabetic kidney injury in a mouse model.
Jeong et al.
PLoS One., 2016;11
Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence.
Boe et al.
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