TM 5441

Catalog # Availability Size / Price Qty
6194/50
6194/10
Cat.No. 6194 - TM 5441 | C21H16ClN2NaO6
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Description: Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Chemical Name: 5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt

Product Details
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Biological Activity

Plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 3.58 - 60.3 μM). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.

Technical Data

Formula:
C21H16ClN2NaO6
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Product Datasheets

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