TNP

Key Product Details

Product Description

TNP is a reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC₅₀ = 0.47 μM for inhibition of InsP₇ formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC₅₀ = 10.2 μM). Binds to the ATP binding site of IP3K (K_i = 4.3 μM).

Product Specifications for TNP

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TNP

The following data is based on the product molecular weight 443.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Chang Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase. Chembiochem 2002 PMID: 12210991
• Padmanabhan Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J.Biol.Chem. 2009 PMID: 19208622

Product Documents for TNP