Catalog Number: 3946
Chemical Name: N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-9H-Purine-2,6-diamine
Biological Activity
Reversible inositol hexakisphosphate kinase (IP6K) inhibitor (IC50 = 0.47 μM for inhibition of InsP7 formation). Also inhibits inositol 1,4,5-trisphosphate 3-kinase (IP3K) (IC50 = 10.2 μM). Binds to the ATP binding site of IP3K (Ki = 4.3 μM).
Technical Data
  • M.Wt:
    443.38
  • Formula:
    C20H16F3N7O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    519178-28-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of a selective inhibitor of inositol hexakisphosphate kinases. Use in defining biological roles and metabolic relationships of inositol pyrophosphates.
    Padmanabhan et al.
    J.Biol.Chem., 2009;284:10571
  2. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase.
    Chang et al.
    Chembiochem, 2002;3:897

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