Tocriscreen GPCR Compound Library

Key Product Details

Key Format Details

• 96-well racks with Matrix storage tubes & SepraSeal caps
• Pre-dissolved in DMSO
• Compounds arranged 80 per rack with 3 racks per library

• Many compounds are exclusive to Tocris
• Full chemical and biological data available
• Exceptional purity

Major GPCR subfamilies covered by Tocriscreen GPCR Library. Peptide Receptors (20%), 5-HT Receptors (10%), Chemokine Receptors (8%), Adenosine Receptors (7%), Adrenergic Receptors (7%), Dopamine Receptors (6%), mGlu Receptors (5%), Opioid Receptors (4%), Muscarinic Receptors (4%), S1P Receptors (4%), Other (26%).

Product Description

Tocriscreen GPCR Compound Library is a library of 240 compounds (100 μl, 10 mM) for GPCR research. Contains compounds that target >30 types of GPCR, including peptide receptors, 5-HT receptors, chemokine receptors, adenosine receptors, adrenergic receptors and more. Adapted for popular techniques in drug discovery and cell biology research, including high throughput screening, high content screening, target validation and assay development. Please view the GPCR tree image for a closer look at the pharmacological diversity of this compound library.

Scientific Data Images for Tocriscreen GPCR Compound Library

Class A GPCR phylogenetic tree illustrating the pharmacological diversity of the Tocriscreen GPCR Compound Library.

The 240 compounds in the Tocriscreen GPCR Compound Library target over 120 GPCRs. Targets are evenly spread across all the GPCR classes with a particular focus on class A, mixing well-established targets such as 5-HT and adenosine receptors, as well as orphan GPCRs such as GPR35 and GPR171. To view a larger PDF version of this image, please click on the ‘GPCR tree’ link in the product description.Adapted from GPCRdb (www.gpcrdb.org/ligand/coverage).

Chemical diversity of the Tocriscreen GPCR Compound Library.

The image shows the overlapping chemical space of the 240 compounds in the Tocriscreen GPCR Compound Library (green dots) in relation to the chemical space occupied by the ChEMBL GPCR compound Chemical Space* (grey dots). Each dot represents a unique fingerprint generated from each compound’s 3D molecular structure. The even distribution of the fingerprints of the compounds in the Tocriscreen GPCR Compound Library highlights the chemical diversity of this library.*The ChEMBL GPCR compound Chemical Space used for this study is defined as a subset of ChEMBL with activities < 1 μM on any of the GPCRs listed in ChEMBL, with a molecular weight between 150 and 550 Da, AlogP between (-2) and 6 and a maximum of one Lipinski rule of 5 violation. This subset contains over 77k compounds.

Product Specifications for Tocriscreen GPCR Compound Library

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

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Product Documents for Tocriscreen GPCR Compound Library