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Tocriscreen Kinase Inhibitor Library

Catalog #: 6268
19 Citations Datasheet / COA / SDS

Discontinued Product

6268 has been discontinued.
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Tocriscreen Kinase Inhibitor Library | Compound Libraries
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Description: A bioactive compound library of 160 kinase inhibitors (250 μL 10 mM DMSO solutions) for high-throughput screening, high-content screening and chemical biology applications
Product Details
Citations (19)
Reviews
Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

Tocriscreen Kinase Inhibitor Library is a collection of 160 kinase inhibitors supplied pre-dissolved in DMSO (250 μL 10 mM solution). The Tocriscreen Kinase Inhibitor Library contains compounds targeting >60 different kinases, including extensive coverage of well-established targets such as VEFGR, AKT and TGFβR as well as more novel targets such as LIMK, Hapsin, NUAK1 and DYRK.

If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.

Key Format and Product Details

  • 96-well racks with Matrix storage tubes & SepraSeal caps
  • Pre-dissolved in DMSO
  • Compounds arranged 80 per rack with two racks per library
  • Many compounds are exclusive to Tocris
  • Full chemical and biological data available
  • Exceptional purity
Target Classes Covered by the Tocriscreen Kinases Inhibitors Library

The Tocriscreen Kinase Inhibitors Library contains bioactive compounds covering a diverse range of kinases, including established enzymes and more novel targets.

Request Compound List

A list of the compounds available in the Tocriscreen Kinase Inhibitor Library can be requested in Excel or SD format via our Tocriscreen & Custom Library Inquiries form.

Technical Data

Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
The Compound list for this product may be requested from www.tocris.com/screening

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
SDS
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Citations for Tocriscreen Kinase Inhibitor Library

The citations listed below are publications that use Tocris products. Selected citations for Tocriscreen Kinase Inhibitor Library include:

19 Citations: Showing 1 - 10

  1. Discovery and characterization of multiple classes of human CatSper blockers.
    Authors: Carlson Et al.
    Chem Med Chem  2022;17:e202000499
  2. Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery.
    Authors: Gull Et al.
    Cold Spring Harb.Protoc.  2022;
  3. A screen of kinase inhibitors reveals a potential role of Chk1 in regulating Hydra head regeneration and maintenance.
    Authors: Lee Et al.
    Int J Dev Biol  2021;65:523
  4. Chemical manipulation of abscisic acid signaling: a new approach to abiotic and biotic stress management in agriculture.
    Authors: Hewage Et al.
    Adv.Sci.  2020;7:2001265
  5. A Novel Three-Dimensional Glioma Blood-Brain Barrier Model for High-Throughput Testing of Tumoricidal Capability.
    Authors: Sherman and Rossi
    Front Oncol  2019;9:351
  6. NTRK1 is a positive regulator of YAP oncogenic function.
    Authors: Yang Et al.
    Oncogene  2019;38:2778
  7. Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells.
    Authors: Chaudhari Et al.
    Stem Cells  2019;37:306
  8. Cheminformatics tools for analyzing and designing optimized small-molecule collections and libraries.
    Authors: Moret Et al.
    Cell Chem Biol  2019;26:765
  9. EGFR-Aurka signaling rescues polarity and regeneration defects in dystrophin-deficient muscle stem cells by increasing asymmetric divisions.
    Authors: Wang Et al.
    Cell Stem Cell  2019;24:419
  10. A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis.
    Authors: Azad Et al.
    Nat Commun  2018;9:1061
  11. GSK3 is a negative regulator of the thermogenic program in brown adipocytes.
    Authors: Markussen Et al.
    Sci.Rep.  2018;8:3469
  12. Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.
    Authors: Tomilov Et al.
    Pharmacol Res  2018;137:89
  13. 1-Benzyl-3-cetyl-2-methylimidazolium Iodide (NH125) Is a Broad-Spectrum Inhibitor of Virus Entry with Lysosomotropic Features.
    Authors: Moeschler Et al.
    Viruses  2018;10:E306
  14. Protocols for the design of kinase-focused compound libraries.
    Authors: Jacoby Et al.
    Mol Inform  2017;37:e1700119
  15. p70S6K is regulated by focal adhesion kinase and is required for Src-selective autophagy.
    Authors: Sandilands Et al.
    Cell Signal.  2015;27:1816
  16. SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest.
    Authors: Tandon Et al.
    PLoS One  2015;10:e0119346
  17. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
    Authors: FitzGerald Et al.
    PLoS One  2014;9:e98891
  18. Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.
    Authors: Acevedo Et al.
    J Biol Chem  2014;289:11007
  19. Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.
    Authors: Moujalled Et al.
    PLoS One  2013;8:e67433

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