DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin
(Cat. No. 1100). Orally bioavailable.
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In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells.
Uckun et al.
A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma.
Sottile et al.
Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
Schellens et al.
The citations listed below are publications that use Tocris products. Selected citations for Topotecan hydrochloride include:
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