Topotecan hydrochloride

Tocris Bioscience | Catalog # 4562

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog
Tocris Bioscience
Discontinued Product
4562 has been discontinued. View all DNA Topoisomerase Inhibitors products.

Key Product Details

Description

DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog

Alternative Names

SK&F 104864-A
View all DNA Topoisomerase Inhibitors »

Product Description

Topotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.

Product Specifications for Topotecan hydrochloride

Molecular Weight

457.91

Formula

C23H23N3O5.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride

CAS Number

119413-54-6

PubChem ID

60699

InChI Key

DGHHQBMTXTWTJV-BQAIUKQQSA-N

SMILES

OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2)C2=C1CN(C)C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 45.79 100
DMSO 45.79 100

Preparing Stock Solutions for Topotecan hydrochloride

The following data is based on the product molecular weight 457.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.92 mL 21.84 mL
5 mM 0.44 mL 2.18 mL 4.37 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for Topotecan hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Topotecan hydrochloride

For research use only

Citations for Topotecan hydrochloride

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