Chemical Name: 10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
Biological ActivityTopotecan hydrochloride is a DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable. Topotecan disrupts the interaction between NHP2L1 and U4 RNA by binding to U4 and inhibits RNA splicing.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
Schellens et al.
A chemical screen identifies the chemotherapeutic drug topo. as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma.
Sottile et al.
Citations for Topotecan hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Topotecan hydrochloride include:
3 Citations: Showing 1 - 3
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
Authors: Balmus Et al.
Nat Commun 2019;10:87
Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
Authors: Florea Et al.
Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.
Authors: Pearson Et al.
Int J Mol Med 2016;7:11173
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