Topotecan hydrochloride

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4562/10
4562/50
Topotecan hydrochloride | CAS No. 119413-54-6 | DNA Topoisomerase Inhibitors
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Description: DNA topoisomerase I inhibitor; Camptothecin (Cat. No. 1100) analog
Alternative Names: SK&F 104864-A

Chemical Name: 10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity

DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable.

Technical Data

M.Wt:
457.91
Formula:
C23H23N3O5.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
119413-54-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Topotecan hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Topotecan hydrochloride include:

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