Catalog Number: 4562
Alternate Names: SK&F 104864-A
Chemical Name: 10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
Biological Activity
DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis ALL; downregulates B-Myb and MycN expression in neuroblastoma cells. Water-soluble analog of Camptothecin (Cat. No. 1100). Orally bioavailable.
Technical Data
  • M.Wt:
    457.91
  • Formula:
    C23H23N3O5.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    119413-54-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vitro and in vivo activity of topotecan against human B-lineage acute lymphoblastic leukemia cells.
    Uckun et al.
    Blood, 1995;85:2817
  2. A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma.
    Sottile et al.
    Oncotarget., 2012;3:535
  3. Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
    Schellens et al.
    Br.J.Cancer, 1996;73:1268
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Topotecan hydrochloride include:

1 Citations: Showing 1 - 1

  1. Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.
    Authors: Pearson Et al.
    Int J Mol Med 2016;7:11173
Tocris Small Molecules
Description Application Cat# Citations Images  

Camptothecin

1100 5  
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