Adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.
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Inhibition of phosphatidylinositol kinase by toyocamycin.
Nishioka et al.
J.Antibiot. (Tokyo)., 1990;43:1586
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
Yen et al.
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.
Ri et al.