Chemical Name: 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
Biological ActivityToyocamycin is an adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines.
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Complete Your Research
Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.
Ri et al.
Inhibition of phosphatidylinositol kinase by toyocamycin.
Nishioka et al.
J.Antibiot. (Tokyo)., 1990;43:1586
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
Yen et al.
Citation for Toyocamycin
The citations listed below are publications that use Tocris products. Selected citations for Toyocamycin include:
1 Citation: Showing 1 - 1
IRE1α-XBP1 inhibitors exerted anti-tumor activities in Ewing's sarcoma.
Authors: Tanabe Et al.
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