TP 003

Catalog # Availability Size / Price Qty
TP 003 | CAS No. 628690-75-5 | GABA-A Receptor Agonists
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Description: GABAA partial agonist; acts at benzodiazepine site

Chemical Name: 2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile

Purity: ≥98%

Product Details
Citations (3)
Supplemental Products

Biological Activity

TP 003 is a GABAA receptor partial agonist that demonstrates affinity for the benzodiazepine site. Potentiates GABAA α3 response with high efficacy. Produces anxiolytic-like effects in rodent elevated plus maze via action at GABAA α2 subtype receptors. Also evokes GABAA α1 mediated sedation and GABAA α3 mediated muscle relaxation in mice.

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for TP 003

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