Catalog Number: 4414
Chemical Name: 2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile
Biological Activity
Functionally selective GABAA receptor (α3 subtype) partial agonist. Exhibits affinity for the benzodiazepine binding site on human GABAA receptors. Potentiates the GABA (α3 subtype) response selectively with high efficacy. Produces anxiolytic-like effects in rodent behavioral models of anxiety.
Technical Data
  • M.Wt:
    407.39
  • Formula:
    C23H16F3N3O
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    628690-75-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.
    Fischer et al.
    Psychopharmacology (Berl.), 2011;215:311
  2. Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
    Dias et al.
    J.Neurosci., 2005;25:10682
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TP 003 include:

1 Citations: Showing 1 - 1

  1. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
    Authors: Seifi Et al.
    Gastroenterology 2014;34:10361

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