Chemical Name: 2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile
Biological ActivityFunctionally selective GABAA receptor (α3 subtype) partial agonist. Exhibits affinity for the benzodiazepine binding site on human GABAA receptors. Potentiates the GABA (α3 subtype) response selectively with high efficacy. Produces anxiolytic-like effects in rodent behavioral models of anxiety.
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Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
Dias et al.
Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.
Fischer et al.
Psychopharmacology (Berl.), 2011;215:311
Citation for TP 003
The citations listed below are publications that use Tocris products. Selected citations for TP 003 include:
1 Citation: Showing 1 - 1
Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
Authors: Seifi Et al.
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