Functionally selective GABAA
3 subtype) partial agonist. Exhibits affinity for the benzodiazepine binding site on human GABAA
receptors. Potentiates the GABA (α
3 subtype) response selectively with high efficacy. Produces anxiolytic-like effects in rodent behavioral models of anxiety.
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Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys.
Fischer et al.
Psychopharmacology (Berl.), 2011;215:311
Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
Dias et al.
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