Chemical Name: N-[(1-Methyl-1H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine
Biological ActivityTP-040 is a potent and selective O-GlcNAcase (OGA) inhibitor (IC50 = 46 nM). It increases the level of O-GlcNAcylated protein in human neuroblastoma SH-SY5Y cells (EC50 = 450 nM). It is suitable for in vivo studies and exhibits brain permeability.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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