TP 472

Key Product Details

Product Description

TP 472 is a potent BRD9/7 inhibitor (K_d values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.

Negative Control also available.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the TP 472 probe summary on the SGC website.

Product Specifications for TP 472

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TP 472

The following data is based on the product molecular weight 333.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.00 mL	30.00 mL	59.99 mL
2.5 mM	1.20 mL	6.00 mL	12.00 mL
5 mM	0.60 mL	3.00 mL	6.00 mL
25 mM	0.12 mL	0.60 mL	1.20 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 47 publications citing the usage of this product.

• Hohmann and Vakoc A rationale to target the SWI/SNF complex for cancer therapy. Trends Genet. 2014 PMID: 24932742

Product Documents for TP 472