Chemical Name: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide
Biological ActivityTP 472 is a potent BRD9/7 inhibitor (Kd values are 33 and 340 nM, respectively) Exhibits >30-fold selectivity for BRD9 over other bromodomains except BRD7. Cell permeable and active in vivo.
Negative Control also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A rationale to target the SWI/SNF complex for cancer therapy.
Hohmann and Vakoc et al.
Trends Genet., 2014;30:356
Citation for TP 472
The citations listed below are publications that use Tocris products. Selected citations for TP 472 include:
1 Citation: Showing 1 - 1
A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells.
Authors: Gatchalian Et al.
Nat Commun 2018;9:5139
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