Chemical Name: (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide
Biological ActivityTPPB is a high affinity and cell permeable protein kinase C activator (Ki =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells.
Rezania et al.
A small molecule that directs differentiation of human ESCs into the pancreatic lineage.
Chen et al.
New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα.
Kozikowski et al.
Citations for TPPB
The citations listed below are publications that use Tocris products. Selected citations for TPPB include:
6 Citations: Showing 1 - 6
Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians.
Authors: Robert G Et al.
Generation of insulin-producing pancreatic β cells from multiple human stem cell lines.
Authors: Kristina G Et al.
Nat Protoc 2021;16:4109-4143
Bioinformatic Analyses of miRNA-mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation.
Authors: Kenichiro Et al.
Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells.
Authors: Leonardo Et al.
Nat Biotechnol 2020;38:460-470
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
Authors: Yang Et al.
Cell Stem Cell 2020;27:125
Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction.
Authors: Rudolf Et al.
Cell Rep Med 2020;1:100097
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