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TPPB | CAS No. 497259-23-1 | Protein Kinase C Activators
1 Image
Description: High affinity PKC activator; also APP modulator

Chemical Name: (2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide

Purity: ≥98%

Product Details
Citations (1)

Biological Activity

TPPB is a high affinity and cell permeable protein kinase C activator (Ki =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

Technical Data

Soluble to 50 mM in DMSO
Store at -20°C

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Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for TPPB

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