TPPB

Key Product Details

Product Description

TPPB is a high affinity and cell permeable protein kinase C activator (K_i =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

Product Specifications for TPPB

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TPPB

The following data is based on the product molecular weight 501.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.99 mL	19.94 mL	39.88 mL
2.5 mM	0.80 mL	3.99 mL	7.98 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
25 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 29 publications citing the usage of this product.

• Chen A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat.Chem.Biol. 2009 PMID: 19287398
• Kozikowski New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPα. J.Med.Chem. 2003 PMID: 12540236
• Rezania Reversal of diabetes with Ins-producing cells derived in vitro from human pluripotent stem cells. Nat.Biotechnol. 2014 PMID: 25211370

Product Documents for TPPB