Type II positive allosteric modulator of α
7 nACh receptors (pEC50
= 5.5). Displays no agonist activity at α
7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α
7 nAChRs. Exhibits potency and efficacy similar to PNU 120596
(Cat. No. 2498).
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
Gronlien et al.
Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
Gill et al.