Chemical Name: 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide
Biological ActivityType II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Displays no agonist activity at α7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Exhibits potency and efficacy similar to PNU 120596 (Cat. No. 2498).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
Gronlien et al.
Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
Gill et al.
Citation for TQS
The citations listed below are publications that use Tocris products. Selected citations for TQS include:
1 Citation: Showing 1 - 1
The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice.
Drug Discov Ther 2017;11(4):206
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