Catalog Number: 4233
Chemical Name: 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide
Biological Activity
Type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Displays no agonist activity at α7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Exhibits potency and efficacy similar to PNU 120596 (Cat. No. 2498).
Technical Data
  • M.Wt:
    376.47
  • Formula:
    C22H20N2O2S
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    353483-92-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
    Gronlien et al.
    Mol.Pharmacol., 2007;72:715
  2. Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
    Gill et al.
    Proc.Natl.Acad.Sci., 2011;108:5867

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