TQS

Key Product Details

Product Description

TQS is a type II positive allosteric modulator of α7 nACh receptors (pEC₅₀ = 5.5). Displays no agonist activity at α7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Exhibits potency and efficacy similar to PNU 120596 (Cat. No. 2498).

Product Specifications for TQS

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TQS

The following data is based on the product molecular weight 376.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.31 mL	26.56 mL	53.13 mL
2.5 mM	1.06 mL	5.31 mL	10.63 mL
5 mM	0.53 mL	2.66 mL	5.31 mL
25 mM	0.11 mL	0.53 mL	1.06 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Gill Agonist activation of α₇ nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci.
• Gronlien Distinct profiles of α₇ nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol.Pharmacol. 2007 PMID: 17565004

Product Documents for TQS