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TQS

4233 1 Citation Datasheet / COA / SDS
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4233/50
TQS | CAS No. 353483-92-8 | Nicotinic (a7) Receptor Modulators
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Description: Positive allosteric modulator of α7 nAChRs

Chemical Name: 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5). Displays no agonist activity at α7 receptors at concentrations up to 0.1 mM; potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Exhibits potency and efficacy similar to PNU 120596 (Cat. No. 2498).

Technical Data

M.Wt:
376.47
Formula:
C22H20N2O2S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
353483-92-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
    Gronlien et al.
    Mol.Pharmacol., 2007;72:715
  2. Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
    Gill et al.
    Proc.Natl.Acad.Sci., 2011;108:5867

Product Datasheets

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Citation for TQS

The citations listed below are publications that use Tocris products. Selected citations for TQS include:

1 Citation: Showing 1 - 1

  1. The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice.
    Authors: Abbas
    Drug Discov Ther  2017;11(4):206

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VersaClone cDNA Plasmids

Human nAChR alpha 7/CHRNA7 (NP_000737) VersaClone cDNA

RDC0282

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