Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Biological ActivityPotent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
TRAM-34 inhibits nonselective cation channels.
Schilling and Eder
Pflugers Arch., 2007;454:559
An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum.
Wang et al.
Pflugers Arch., 2007;454:945
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
Wulff et al.
Proc.Natl.Acad.Sci. USA, 2000;97:8151
Citations for TRAM 34
The citations listed below are publications that use Tocris products. Selected citations for TRAM 34 include:
10 Citations: Showing 1 - 10
Functional cooperation between KCa3.1 and TRPV4 channels in bronchial smooth muscle cell proliferation associated with chronic asthma.
Front. Pharmacol 2017;8:559
Piezo1 links mechanical forces to red blood cell volume.
Authors: Cahalan Et al.
J Biomed Sci 2015;4
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
Authors: Mazzuca Et al.
J Pharmacol Exp Ther 2015;352:291
5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
Authors: Chien and Su
PLoS One 2015;22:42
TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity.
Authors: Agarwal Et al.
FASEB J 2013;8:e63028
Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1).
Authors: Kanthesh Et al.
Am J Physiol Cell Physiol 2013;305:C972
Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
Authors: Benton Et al.
J Neurophysiol 2013;109:2528
Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells.
Authors: Engbers Et al.
Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ.
Authors: Chan and Cipolla
JCI Insight 2011;25:3229
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Authors: Zemkova Et al.
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Product used for understanding blocking mechanism of calcium activated potassium channel. Product must be dissolved in DMSO, on mild heat. Shows great potential for research in KCa channel studies.