Catalog Number: 2946
Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Biological Activity
Potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
Technical Data
  • M.Wt:
    344.84
  • Formula:
    C22H17ClN2
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    289905-88-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TRAM-34 inhibits nonselective cation channels.
    Schilling and Eder
    Pflugers Arch., 2007;454:559
  2. An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum.
    Wang et al.
    Pflugers Arch., 2007;454:945
  3. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
    Wulff et al.
    Proc.Natl.Acad.Sci. USA, 2000;97:8151
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