TRAM 34 (CAS 289905-88-0): R&D Systems
Catalog Number: 2946
Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Biological Activity
Potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
Technical Data
  • M.Wt:
    344.84
  • Formula:
    C22H17ClN2
  • Solubility:
    Soluble to 10 mM in DMSO with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    289905-88-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TRAM-34 inhibits nonselective cation channels.
    Schilling and Eder
    Pflugers Arch., 2007;454:559
  2. An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum.
    Wang et al.
    Pflugers Arch., 2007;454:945
  3. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
    Wulff et al.
    Proc.Natl.Acad.Sci. USA, 2000;97:8151
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TRAM 34 include:

9 Citations: Showing 1 - 9
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  1. Functional cooperation between KCa3.1 and TRPV4 channels in bronchial smooth muscle cell proliferation associated with chronic asthma.
    Authors: Yu
    Front. Pharmacol 2017;8:559
  2. Piezo1 links mechanical forces to red blood cell volume.
    Authors: Cahalan Et al.
    J Biomed Sci 2015;4
  3. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
    Authors: Mazzuca Et al.
    J Pharmacol Exp Ther 2015;352:291
  4. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
    Authors: Chien and Su
    PLoS One 2015;22:42
  5. TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity.
    Authors: Agarwal Et al.
    FASEB J 2013;8:e63028
  6. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol 2013;109:2528
  7. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells.
    Authors: Engbers Et al.
    Elife 2012;109:2601
  8. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ.
    Authors: Chan and Cipolla
    JCI Insight 2011;25:3229
  9. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology 2011;152:3842
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