Catalog # Availability Size / Price Qty
TRAM 34 | CAS No. 289905-88-0 | Ca2+-Activated Potassium Channel Blockers
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Description: Potent and highly selective KCa3.1 (IK) channel blocker

Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

Purity: ≥99%

Product Details
Citations (10)

Biological Activity

TRAM 34 is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

Technical Data

Soluble to 10 mM in DMSO with gentle warming
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Background References

  1. TRAM-34 inhibits nonselective cation channels.
    Schilling and Eder
    Pflugers Arch., 2007;454:559
  2. An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum.
    Wang et al.
    Pflugers Arch., 2007;454:945
  3. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
    Wulff et al.
    Proc.Natl.Acad.Sci. USA, 2000;97:8151

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Citations for TRAM 34

The citations listed below are publications that use Tocris products. Selected citations for TRAM 34 include:

10 Citations: Showing 1 - 10

  1. Functional cooperation between KCa3.1 and TRPV4 channels in bronchial smooth muscle cell proliferation associated with chronic asthma.
    Authors: Yu
    Front. Pharmacol  2017;8:559
  2. Piezo1 links mechanical forces to red blood cell volume.
    Authors: Cahalan Et al.
    J Biomed Sci  2015;4
  3. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
    Authors: Mazzuca Et al.
    J Pharmacol Exp Ther  2015;352:291
  4. 5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
    Authors: Chien and Su
    PLoS One  2015;22:42
  5. TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity.
    Authors: Agarwal Et al.
    FASEB J  2013;8:e63028
  6. Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1).
    Authors: Kanthesh Et al.
    Am J Physiol Cell Physiol  2013;305:C972
  7. Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
    Authors: Benton Et al.
    J Neurophysiol  2013;109:2528
  8. Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells.
    Authors: Engbers Et al.
    Elife  2012;109:2601
  9. Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ.
    Authors: Chan and Cipolla
    JCI Insight  2011;25:3229
  10. NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842


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