Potent and highly selective blocker of intermediate conductance Ca2+
= 20 nM). Exhibits 200-1500-fold selectivity over KV
, CRAC and Cl-
channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
TRAM-34 inhibits nonselective cation channels.
Schilling and Eder
Pflugers Arch., 2007;454:559
An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum.
Wang et al.
Pflugers Arch., 2007;454:945
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
Wulff et al.
Proc.Natl.Acad.Sci. USA, 2000;97:8151
The citations listed below are publications that use Tocris products. Selected citations for TRAM 34 include:
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