Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole
Biological ActivityTRAM 34 is a potent and highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
TRAM-34 inhibits nonselective cation channels.
Schilling and Eder
Pflugers Arch., 2007;454:559
An intermediate-conductance Ca2+-activated K+ channel mediates B lymphoma cell cycle progression induced by serum.
Wang et al.
Pflugers Arch., 2007;454:945
Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.
Wulff et al.
Proc.Natl.Acad.Sci. USA, 2000;97:8151
Citations for TRAM 34
The citations listed below are publications that use Tocris products. Selected citations for TRAM 34 include:
10 Citations: Showing 1 - 10
Functional cooperation between KCa3.1 and TRPV4 channels in bronchial smooth muscle cell proliferation associated with chronic asthma.
Front. Pharmacol 2017;8:559
Piezo1 links mechanical forces to red blood cell volume.
Authors: Cahalan Et al.
J Biomed Sci 2015;4
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
Authors: Mazzuca Et al.
J Pharmacol Exp Ther 2015;352:291
5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
Authors: Chien and Su
PLoS One 2015;22:42
TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity.
Authors: Agarwal Et al.
FASEB J 2013;8:e63028
Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1).
Authors: Kanthesh Et al.
Am J Physiol Cell Physiol 2013;305:C972
Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
Authors: Benton Et al.
J Neurophysiol 2013;109:2528
Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells.
Authors: Engbers Et al.
Relaxin causes selective outward remodeling of brain parenchymal arterioles via activation of peroxisome proliferator-activated receptor-γ.
Authors: Chan and Cipolla
JCI Insight 2011;25:3229
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Authors: Zemkova Et al.
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Product used for understanding blocking mechanism of calcium activated potassium channel. Product must be dissolved in DMSO, on mild heat. Shows great potential for research in KCa channel studies.