TRAM 39

Catalog # Availability Size / Price Qty
4952/25
4952/5

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TRAM 39 | CAS No. 197525-99-8 | Ca2+-Activated Potassium Channel Blockers
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Description: Potent KCa3.1 (IK) blocker

Chemical Name: 2-Chloro-α,α-diphenylbenzeneacetonitrile

Purity: ≥99%

Product Details
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Biological Activity

TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.

Technical Data

M.Wt:
303.78
Formula:
C20H14ClN
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
197525-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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