TRAM 39

Tocris Bioscience | Catalog # 4952

Potent KCa3.1 (IK) blocker
Tocris Bioscience
Discontinued Product
4952 has been discontinued. View all Ca2+-Activated Potassium Channel Blockers products.

Key Product Details

Description

Potent KCa3.1 (IK) blocker
View all Ca2+-Activated Potassium Channel Blockers »

Product Description

TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM). Has no effect on cytochrome p450 activity. Inhibits I-EBIO-stimulated increases in rat artery membrane potential ex vivo. Also diminishes LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro.

Product Specifications for TRAM 39

Molecular Weight

303.78

Formula

C20H14ClN

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

2-Chloro-α,α-diphenylbenzeneacetonitrile

CAS Number

197525-99-8

PubChem ID

9861261

InChI Key

JHNRTPKGSCVKKC-UHFFFAOYSA-N

SMILES

ClC(C=CC=C3)=C3C(C2=CC=CC=C2)(C#N)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.44 50

Preparing Stock Solutions for TRAM 39

The following data is based on the product molecular weight 303.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 6.58 mL 32.92 mL 65.84 mL
2.5 mM 1.32 mL 6.58 mL 13.17 mL
5 mM 0.66 mL 3.29 mL 6.58 mL
25 mM 0.13 mL 0.66 mL 1.32 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for TRAM 39

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TRAM 39

For research use only

Related Research Areas

Ion Channels and Regulators

Customer Reviews for TRAM 39 (1)

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  • Selective blocker worked ideally to block Calcium activated K+ channels
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: HEK 293
    Verified Customer | Posted 10/22/2018
    Product was used on BK channel.Calcium activated potassium channels were expressed by HEK 293 cells which was used for the study.It shows moderate blocking activity and the data patterns were similar throughout the study.
    TRAM 39 4952

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