Q: I can’t find functionality of this protein. Do you have the function test of this protein?

A: Unfortunately, NBP1-72339 has not yet been tested for functional use. It has only been tested as a positive control protein for use in SDS PAGE gels. As we do not yet have this type of data for this protein, we would not be able to provide a guarantee for this type of application at this time.

Recombinant Human TRANCE/TNFSF11/RANK L His Protein

Novus Biologicals | Catalog # NBP1-72339

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Product Documents

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Product Specifications
Scientific Data
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE

View all TRANCE/TNFSF11/RANK L Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 140-317 of Human TRANCE/TNFSF11/RANK L

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MIRAEKAMVD GSWLDLAKRS KLEAQPFAHL TINATDIPSG SHKVSLSSWY HDRGWAKISN MTFSNGKLIV NQDGFYYLYA NICFRHHETS GDLATEYLQL MVYVTKTSIK IPSSHTLMKG GSTKYWSGNS EFHFYSINVG GFFKLRSGEE ISIEVSNPSL LDPDQDATYF GAFKVRDID

Purity

>80%, by SDS-PAGE

Predicted Molecular Mass

22.3 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human TRANCE/TNFSF11/RANK L His Protein

SDS-PAGE: Recombinant Human TRANCE/TNFSF11/RANK L His Protein [NBP1-72339]

SDS-Page: Recombinant Human TRANCE/TNFSF11/RANK L Protein [NBP1-72339]

Formulation, Preparation, and Storage

NBP1-72339

Formulation	20 mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1 M NaCl, 1 mM DTT
Preservative	No Preservative
Concentration	0.5 mg/ml
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRANCE/TNFSF11/RANK L

TNFSF11, also known as RANKL, is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. TNFSF11 also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation. TNFSF11 is important in bone metabolism. This natural and necessary surface-bound molecule (also known as CD254) found on osteoblasts serves to activate osteoclasts, which are the cells involved in bone resorption. Recombinant human TNFSF11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Long Name

TNF-related Activation-induced Cytokine

Alternate Names

CD254, ODF, OPGL, RANK L, RANKL, TNFSF11

Gene Symbol

TNFSF11

Additional TRANCE/TNFSF11/RANK L Products

Product Documents for Recombinant Human TRANCE/TNFSF11/RANK L His Protein

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Certificate of Analysis

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Product Specific Notices for Recombinant Human TRANCE/TNFSF11/RANK L His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

Related Research Areas

Regulatory T Cells (Tregs)

T Cell Cytokine Signaling

TNF Superfamily

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