Tranilast

Key Product Details

Product Description

Tranilast is an antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT₁ receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation.

Product Specifications for Tranilast

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tranilast

The following data is based on the product molecular weight 327.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.27 mL	30.55 mL
5 mM	0.61 mL	3.05 mL	6.11 mL
10 mM	0.31 mL	1.53 mL	3.05 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

• Connors Tranilast binds to Aβ monomers and promotes Aβ fibrillation. Biochemistry 2013 PMID: 23679559
• Hisanaga Regulation of calcium-permeable TRPV2 channel by Ins in pancreatic beta-cells. Diabetes. 2009 PMID: 18984736
• Isaji Tranilast inhibits the proliferation, chemotaxis and tube formation of human microvascular endothelial cells in vitro and angiogenesis in vivo. Br.J.Pharmacol. 1997 PMID: 9401770
• Jin Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II. Eur.J.Pharmacol. 1998 PMID: 9865509
• Hishikawa Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells. J.Cardiovasc.Pharmacol. 1996 PMID: 8856474

Product Documents for Tranilast