Catalog Number: 4218
Chemical Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5-heptenoic acid 1-methyethyl ester
Biological Activity
FP prostaglandin receptor agonist. Exhibits submicromolar affinity for DP, EP, IP and TP receptors. Stimulates intracellular Ca2+ mobilization. Ocular hypotensive agent.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 10mg/ml)
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [3H]AL-5848 ([3H]9beta-(+)-Fluprostenol). Carboxylic acid of travoprost (AL-6221), a novel FP prostaglandin to study the pharmacology and autoradiographic localization of the FP receptor.
    Sharif et al.
    J.Pharm.Pharmacol., 1999;51:685
  2. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist.
    Hellberg et al.
    J.Ocul.Pharmacol.Ther., 2001;17:421
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