Biological ActivityTri-GalNAc-biotin is a biotinylated asialoglycoprotein receptor (ASGPR) ligand for lysosomal targeting chimera (LYTAC) research and development, comprising a triantennary N-acetylgalactosamine (GalNAc) joined by a PEG linker to biotin. Tri-GalNAc-biotin can induce ASGPR-mediated endocytosis and trafficking of fluorescently labeled neutravidin for lysosomal degradation in HepG2 cells in a time-dependent manner. The increase in fluorescent signal within cells plateaus after 16-20h, and this effect can be inhibited by addition of tri-GalNAc COOH (Cat. No. 7401).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for tri-GalNAc biotin
There are currently no reviews for this product. Be the first to review tri-GalNAc biotin and earn rewards!
Have you used tri-GalNAc biotin?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image