Catalog Number: 1406
Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Biological Activity
Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Activates autophagy.
Technical Data
  • M.Wt:
    302.37
  • Formula:
    C17H22N2O3
  • Solubility:
    Soluble to 10 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    58880-19-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Reprogramming primordial germ cells into pluripotent stem cells.
    Durcova-Hills et al.
    PloS ONE, 2008;3:e3531
  2. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.
    Yoshida et al.
    J.Biol.Chem., 1990;265:17174
  3. Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A.
    Wharton et al.
    J.Biol.Chem., 2000;275:33981
  4. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.
    Vigushin et al.
    Clin.Cancer Res., 2001;7:971
  5. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Trichostatin A include:

4 Citations: Showing 1 - 4
Filter your results:

  1. Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein.
    Authors: Franklin Et al.
    Neurobiol Learn Mem 2014;114:193
  2. Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2.
    Authors: Biernacka Et al.
    World J Gastroenterol 2013;20:741
  3. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther 2013;14:638
  4. Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines.
    Authors: Kobori Et al.
    Oncogene 2010;16:2355

Have you used Trichostatin A?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information