Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Biological ActivityTrichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (Ki = 3.4 nM, IC50 values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC50 = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Reprogramming primordial germ cells into pluripotent stem cells.
Durcova-Hills et al.
PloS ONE, 2008;3:e3531
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.
Yoshida et al.
Inhibition of mitogenesis in Balb/c-3T3 cells by trichostatin A.
Wharton et al.
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.
Vigushin et al.
Clin.Cancer Res., 2001;7:971
Citations for Trichostatin A
The citations listed below are publications that use Tocris products. Selected citations for Trichostatin A include:
8 Citations: Showing 1 - 8
Trichostatin A Shows Transient Protection from Chronic Alcohol-Induced Reactive Oxygen Species (ROS) Production in Human Monocyte-Derived Dendritic Cells.
Authors: Parira Et al.
J Alcohol Drug Depend 2019;6
Histone deacetylase 4 promotes type I IF. signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Authors: Lu Et al.
Proc Natl Acad Sci U S A 2019;
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Authors: Li Et al.
Nat Commun 2018;9:1420
Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein.
Authors: Franklin Et al.
Neurobiol Learn Mem 2014;114:193
Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2.
Authors: Biernacka Et al.
World J Gastroenterol 2013;20:741
Identification of repurposed small molecule drugs for chordoma therapy.
Authors: Xia Et al.
Cancer Biol Ther 2013;14:638
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Authors: Kurita Et al.
Nat Neurosci 2012;15:1245
Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines.
Authors: Kobori Et al.
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