Trichostatin A

Catalog # Availability Size / Price Qty
1406/1
Trichostatin A | CAS No. 58880-19-6 | Class I Histone Deacetylases Inhibitors
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Description: Potent histone deacetylase inhibitor

Chemical Name: (2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide

Purity: ≥98%

Product Details
Citations (8)
Reviews

Biological Activity

Trichostatin A is a selective and potent inhibitor of class I and II histone deacetylases (HDAC) (Ki = 3.4 nM, IC50 values are 4.99 nM, 5.21 nM, 16.4 nM, 24.3 nM, 27.6 nM for HDAC1, 3, 6, 10 and 4, respectively). Trichostatin A induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Trichostatin A potently inhibits a range of breast cancer and melanoma cell lines (IC50 = 29-400 nM) and induces apoptosis in prostate cancer cells. In an animal model of Huntington's disease, inhibition of HDAC by Trichostatin A rescues memory deficits and increases expression of CREB/CBP target genes in mutant mice. Activates autophagy, increases vesicular transport of BDNF (Cat. No. 2837) and is active in vivo.

Technical Data

M.Wt:
302.37
Formula:
C17H22N2O3
Solubility:
Soluble to 5 mg/ml in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
58880-19-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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