Trichostatin A

  ( 5 citations )    
Product Datasheet
Catalog Number:1406
Chemical Name:(2E,4E,6R)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
Product Details
Citations (5)
Reviews
Biological Activity
Selective and potent inhibitor of histone deacetylase (Ki = 3.4 nM). Active in vivo. Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. Activates autophagy.
Technical Data
  • M.Wt:
    302.37
  • Formula:
    C17H22N2O3
  • Solubility:
    Soluble to 10 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    58880-19-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Trichostatin A include:

5 Citations: Showing 1 - 5
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  1. Increased long-term potentiation at medial-perforant path-dentate granule cell synapses induced by selective inhibition of histone deacetylase 3 requires Fragile X mental retardation protein.
    Authors: Franklin Et al.
    Neurobiol Learn Mem  2014;114:193
  2. Hyperglycaemia-induced chemoresistance of prostate cancer cells due to IGFBP2.
    Authors: Biernacka Et al.
    World J Gastroenterol  2013;20:741
  3. Identification of repurposed small molecule drugs for chordoma therapy.
    Authors: Xia Et al.
    Cancer Biol Ther  2013;14:638
  4. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
    Authors: Kurita Et al.
    Nat Neurosci  2012;15:1245
  5. Butyrate stimulates IL-32α expression in human intestinal epithelial cell lines.
    Authors: Kobori Et al.
    Oncogene  2010;16:2355

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