Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Biological ActivityInhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
XPB, a subunit of TFIIH, is a target of the natural product triptolide.
Titov et al.
Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation.
Qui et al.
PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells.
Lee et al.
Citations for Triptolide
The citations listed below are publications that use Tocris products. Selected citations for Triptolide include:
7 Citations: Showing 1 - 7
Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing.
Authors: Shao Et al.
A Role for FACT in RNA Polymerase II Promoter-Proximal Pausing.
Authors: Tettey Et al.
Cell Rep 2019;27:3770
BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication.
Authors: Bowry Et al.
Cell Rep 2018;25:2061
Site-specific regulation of histone H1 phosphorylation in pluripotent cell differentiation.
Authors: Liao and Mizzen
Epigenetics Chromatin 2017;10:29
Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.
Authors: Zhao Et al.
Sci Rep 2015;5:7647
The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.
Authors: Filone Et al.
PLoS Pathog 2014;10:e1003904
Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).
Authors: Vollmer Et al.
J Biol Chem 2012;287:35212
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