Catalog Number: 3253
Chemical Name: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one
Biological Activity
Inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50 = 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Blocks RNA synthesis in HeLa cells (IC50 = 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and induces apoptosis by blocking TNF-α-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.
Technical Data
  • M.Wt:
    360.4
  • Formula:
    C20H24O6
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    38748-32-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation.
    Qui et al.
    J.Biol.Chem., 1999;274:13443
  2. PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells.
    Lee et al.
    J.Biol.Chem., 1999;274:13451
  3. XPB, a subunit of TFIIH, is a target of the natural product triptolide.
    Titov et al.
    Nat.Chem.Biol., 2011;7:182
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Triptolide include:

2 Citations: Showing 1 - 2
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  1. Hyaluronic acid prevents immunosuppressive drug-induced ovarian damage via up-regulating PGRMC1 expression.
    Authors: Zhao Et al.
    Sci Rep 2015;5:7647
  2. The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.
    Authors: Filone Et al.
    PLoS Pathog 2014;10:e1003904

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