Inhibits DNA-dependent ATPase activity of XBP and induces inhibition of RNA polymerase II (RNAPII)-mediated transcription (IC50
= 200 nM). Selective for RNAPII over RNAPI and RNAPIII. Blocks RNA synthesis in HeLa cells (IC50
= 62 nM); exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50
= 12 nM) and induces apoptosis by blocking TNF-α
-mediated c-IAP1 and c-IAP2 induction. Also displays immunosuppressive and anti-inflammatory activity.
Soluble to 20 mM in DMSO
Store at -20°C
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All Tocris products are intended for laboratory research use only.
Immunosuppressant PG490 (Triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-κB transcriptional activation.
Qui et al.
PG490 (Triptolide) cooperates with tumor necrosis factor-α to induce apoptosis in tumor cells.
Lee et al.
XPB, a subunit of TFIIH, is a target of the natural product triptolide.
Titov et al.
The citations listed below are publications that use Tocris products. Selected citations for Triptolide include:
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