Troglitazone

Catalog # Availability Size / Price Qty
3114/10
3114/50
Troglitazone | CAS No. 97322-87-7 | PPAR gamma Receptor Agonists
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Description: Selective PPARγ agonist; antidiabetic agent
Alternative Names: Rezulin

Chemical Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione

Purity: ≥97%

Product Details
Citations (3)
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Biological Activity

Selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

Technical Data

M.Wt:
441.54
Formula:
C24H27NO5S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
97322-87-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Troglitazone

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