Troglitazone

Key Product Details

Product Description

Troglitazone is a selective PPARγ receptor agonist (EC₅₀ values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.

Product Specifications for Troglitazone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Troglitazone

The following data is based on the product molecular weight 441.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Fujimura Effects of troglitazone on the growth and differentiation of hematopoietic cell lines. Int.J.Oncol. 1998 PMID: 9824642
• Kodera Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators. J.Biol.Chem. 2000 PMID: 10944516
• Willson The PPARs: from orphan receptors to drug discovery. J.Med.Chem. 2000 PMID: 10691680
• Lee and Olefsky Acute effects of troglitazone on in vivo Ins action in normal rats. Metabolism 1995 PMID: 7666790

Product Documents for Troglitazone