Troglitazone

  ( 2 citations )    
Product Datasheet
Catalog Number:3114
Alternate Names:Rezulin
Chemical Name:5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Product Details
Citations (2)
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Reviews
Biological Activity
Selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.
Technical Data
  • M.Wt:
    441.54
  • Formula:
    C24H27NO5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    97322-87-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Troglitazone include:

2 Citations: Showing 1 - 2
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  1. Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib.
    Authors: Ross Et al.
    Cell Chem Biol  2017;24:813
  2. Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo.
    Authors: Hegde Et al.
    J Immunol  2015;194:5211

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