Chemical Name: 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
Biological ActivityTroglitazone is a selective PPARγ receptor agonist (EC50 values are 780 and 555 nM at murine and human PPARγ receptors respectively). Displays no activity at PPARα or PPARδ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits cell growth of hematopoietic cell lines. Inhibits lamellipodia formation and actin polymerization.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Acute effects of troglitazone on in vivo Ins action in normal rats.
Lee and Olefsky
Ligand type-specific interactions of peroxisome-proliferator-activated receptor γ with transcriptional coactivators.
Kodera et al.
The PPARs: from orphan receptors to drug discovery.
Willson et al.
Effects of troglitazone on the growth and differentiation of hematopoietic cell lines.
Fujimura et al.
Citations for Troglitazone
The citations listed below are publications that use Tocris products. Selected citations for Troglitazone include:
3 Citations: Showing 1 - 3
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and sora.
Authors: Ross Et al.
Cell Chem Biol 2017;24:813
Elucidation and Pharmacological Targeting of Novel Molecular Drivers of Follicular Lymphoma Progression.
Authors: Bisikirska Et al.
Cancer Res 2016;76:664
Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo.
Authors: Hegde Et al.
J Immunol 2015;194:5211
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