TROP-2 Antibody [ADC] - (Sacituzumab Vedotin, Research Grade)

Novus Biologicals | Catalog # NBP3-44558

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

ADC

Antibody Source

Monoclonal Human IgG1
View all TROP-2 Primary Antibodies »

Product Specifications

Immunogen

TROP-2 (Uniprot: P09758)

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Theoretical MW

150 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

This product is an Antibody-Drug Conjugate (ADC) for Research Use Only (RUO).

The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 146.06 kDa.

This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for TROP-2 Antibody [ADC] - (Sacituzumab Vedotin, Research Grade)

Hu TROP-2 mAb [ADC] - (Sacituzumab Vedotin) [NBP3-44558] -

In vivo assay: Hu TROP-2 mAb [ADC] - (Sacituzumab Vedotin) [NBP3-44558] -

TROP-2 (Sacituzumab Vedotin) Antibody inhibited the tumor growth of MDA-MB-231 on NSG mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 80.0% at 5 mpk at D37.
Hu TROP-2 mAb [ADC] - (Sacituzumab Vedotin) [NBP3-44558] -

Functional: Hu TROP-2 mAb [ADC] - (Sacituzumab Vedotin) [NBP3-44558] -

Killing assay test on NCL-H292 Cells,the maximum kill rate of anti-TROP-2 (Sacituzumab Vedotin) Antibody is about 100%.

Applications for TROP-2 Antibody [ADC] - (Sacituzumab Vedotin, Research Grade)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Spectra Viewer

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectra Viewer
Spectra Viewer

Flow Cytometry Panel Builder

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Save time and reduce costly mistakes by quickly finding compatible reagents using the Panel Builder Tool.

Advanced Features

  • Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
  • Spillover Popups - Visualize the spectra of individual fluorochromes
  • Antigen Density Selector - Match fluorochrome brightness with antigen density
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Flow Cytometry

Formulation, Preparation, and Storage

Purification

> 90% by SDS-PAGE and HPLC

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: TROP-2

TROP2 encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. [provided by RefSeq]

Long Name

Tumor-associated Calcium Signal Transducer 2

Alternate Names

GA733-1, gp50, T16, TACSTD2, TROP2

Additional TROP-2 Products

Product Documents for TROP-2 Antibody [ADC] - (Sacituzumab Vedotin, Research Grade)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for TROP-2 Antibody [ADC] - (Sacituzumab Vedotin, Research Grade)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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FAQs

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