Catalog Number: 2459
Alternate Names: Novaban, ICS 205930
Chemical Name: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Biological Activity
Potent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR.
Technical Data
  • M.Wt:
    320.82
  • Formula:
    C17H20N2O2.HCl
  • Solubility:
    Soluble to 100 mM in water and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    105826-92-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granisetron and tropisetron.
    Seynaeve et al.
    Anticancer Drugs, 1991;2:343
  2. Centrally active 5-HT receptor agonists and antagonists.
    Middlemiss and Tricklebank
    Neurosci.Biobehav.Rev., 1992;16:75
  3. 5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake.
    Mhatre et al.
    Eur.J.Pharmacol., 2004;491:149
  4. Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.
    Papke et al.
    Bioorg.Med.Chem.Lett., 2004;14:1849
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tropisetron hydrochloride include:

4 Citations: Showing 1 - 4
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  1. Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
    Authors: Otvos Et al.
    Respir Physiol Neurobiol 2015;7:2336
  2. Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism.
    Authors: Johnson Et al.
    Proc Natl Acad Sci U S A 2015;207:48
  3. The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.
    Authors: Spilman Et al.
    Brain Res 2014;1551:25
  4. Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea.
    Authors: Sendin Et al.
    Mol Cell Biol 2014;111:1999

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