Chemical Name: (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Biological ActivityPotent, orally active 5-HT3 receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR. Activates α7Q79G-GlyR chimeric ion channels (EC50 = 38 nM)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Activity of α7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.
Papke et al.
Centrally active 5-HT receptor agonists and antagonists.
Middlemiss and Tricklebank
5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake.
Mhatre et al.
5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granis. and tropisetron.
Seynaeve et al.
Anticancer Drugs, 1991;2:343
Citations for Tropisetron hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Tropisetron hydrochloride include:
4 Citations: Showing 1 - 4
Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
Authors: Otvos Et al.
Respir Physiol Neurobiol 2015;7:2336
Hypoxia switches episodic breathing to singlet breathing in red-eared slider turtles (Trachemys scripta) via a tropisetron-sensitive mechanism.
Authors: Johnson Et al.
Proc Natl Acad Sci U S A 2015;207:48
The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model.
Authors: Spilman Et al.
Brain Res 2014;1551:25
Spatiotemporal pattern of action potential firing in developing inner hair cells of the mouse cochlea.
Authors: Sendin Et al.
Mol Cell Biol 2014;111:1999
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