Tropisetron hydrochloride

Key Product Details

Product Description

Tropisetron hydrochloride is a potent, orally active 5-HT₃ receptor antagonist. Antiemetic. Also partial agonist of α7 nAChR. Activates α7^Q79G-GlyR chimeric ion channels (EC₅₀ = 38 nM)

Product Specifications for Tropisetron hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tropisetron hydrochloride

The following data is based on the product molecular weight 320.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.12 mL	15.59 mL	31.17 mL
5 mM	0.62 mL	3.12 mL	6.23 mL
10 mM	0.31 mL	1.56 mL	3.12 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Papke Activity of α7-selective agonists at nicotinic and serotonin 5HT₃ receptors expressed in Xenopus oocytes. Bioorg.Med.Chem.Lett. 2004 PMID: 15050614
• Middlemiss and Tricklebank Centrally active 5-HT receptor agonists and antagonists. Neurosci.Biobehav.Rev. 1992 PMID: 1553108
• Mhatre 5-HT₃ antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake. Eur.J.Pharmacol. 2004 PMID: 15140631
• Seynaeve 5-HT3 receptor antagonists, a new approach in emesis: a review of ondansetron, granis. and tropisetron. Anticancer Drugs 1991 PMID: 1665723

Product Documents for Tropisetron hydrochloride