Trovafloxacin mesylate

Tocris Bioscience | Catalog # 3863

Antibiotic; inhibits bacterial DNA synthesis
Tocris Bioscience

Key Product Details

Description

Antibiotic; inhibits bacterial DNA synthesis

Alternative Names

CP 99219
View all Antibiotics »

Product Description

Trovafloxacin mesylate is a fluoroquinolone antibiotic. Inhibits bacterial DNA topoisomerase IV and DNA gyrase and forms a stable quinolone-DNA complex with these enzymes which reversibly inhibits DNA synthesis. Displays potent activity against gram-positive and gram-negative bacteria. Increases the production of mitochondrial NO in immortalized hepatocytes; also increases mitochondrial Ca2+. Inhibits Panx-1 (IC50 ~ 4μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Trovafloxacin mesylate

Molecular Weight

512.46

Formula

C20H15F3N4O3.CH3SO3H

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

7-[(1α,5α,6α)-6-Amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid mesylate

CAS Number

147059-75-4

PubChem ID

62960

InChI Key

DYNZICQDCVYXFW-GIPYJWDTSA-N

SMILES

O=C2C1=CC(F)=C(N4C[C@@]([C@H]5N)([H])[C@@]5([H])C4)N=C1N(C3=C(F)C=C(F)C=C3)C=C2C(O)=O.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 25.62 50
DMSO 51.25 100

Preparing Stock Solutions for Trovafloxacin mesylate

The following data is based on the product molecular weight 512.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.76 mL 19.51 mL
5 mM 0.39 mL 1.95 mL 3.90 mL
10 mM 0.20 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Trovafloxacin mesylate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Trovafloxacin mesylate

For research use only

Citations for Trovafloxacin mesylate

Customer Reviews for Trovafloxacin mesylate (1)

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  • Hepatoxic side effects of Trovafloxacin was studied against other several quinolones
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 12/15/2019
    Hepatoxic side effects of Trovafloxacin was studied against other several quinolones (temafloxacin, sparfloxacin, grepafloxacin, trovafloxacin) which have been withdrawn or their use severely limited soon after their clinical introduction owing to severe and sometimes life-threatening adverse events.
    Trovafloxacin mesylate 3863

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