TRPC6 Antibody

Name: TRPC6 Antibody
Brand: Novus Biologicals
SKU: NBP1-52635
Price: 459 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-52635

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

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Product Specifications

Immunogen

The immunogen for this product maps to a region between residue 350 and 400 of human Transient Receptor Potential Cation Channel, Subfamily C, Member 6 using the numbering given in entry NP_004612.2 (GeneID 7225).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRPC6 Antibody

Western Blot: TRPC6 Antibody [NBP1-52635]

Western Blot: TRPC6 Antibody [NBP1-52635] - Affinity purified rabbit anti-TRPC6 antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 6 mcg/mg lysate.

Applications for TRPC6 Antibody

Application

Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000

Application Notes

Western blot of lysates performed using standard western blot reagents and 4-8% SDS-PAGE.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TRPC6

TRPC6, also known as TRP6, short transient receptor potential channel 6 and transient receptor potential cation channel subfamily C member 6, is thought to form a receptor-activated non-selective calcium permeant cation channel. TRPC6 is probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. It is activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C and may not to be activated by intracellular calcium store depletion. Defects in this gene are a cause of focal segmental glomerulosclerosis (FSGS). Expression of this protein has been reported in tissues such as placenta, lung, spleen, ovary, small intestine, and renal podocytes. Immunohistochemistry studies using polyclonal antibodies to this target have shown moderate to strong staining in cell types such as neurons, breast, respiratory, squamous and prostate epithelium, epidermis, placental trophoblasts, dendritic cells, and subsets of immune cells, and faint to moderate staining of adrenal, colon, ganglion cells, hepatocytes, heart, and testis.

Long Name

Short transient receptor potential channel 6

Alternate Names

FSGS2, TRP-6, TRP6

Entrez Gene IDs

7225 (Human)

Gene Symbol

TRPC6

UniProt

Q9Y210 (Human)

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Product Documents for TRPC6 Antibody

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Certificate of Analysis

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Product Specific Notices for TRPC6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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