TSC22/TSC22D1 Antibody

Novus Biologicals | Catalog # NBP2-24628

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Canine

Predicted:

Bovine (100%), Chicken (100%), Chimpanzee (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all TSC22 Primary Antibodies »

Product Specifications

Immunogen

A portion of amino acids 100-150 of human TSC22 was used as the immunogen.

Reactivity Notes

The amino acid sequence used as immunogen is 86% homologous in Zebrafish.

Specificity

This antibody may also recognize TSC22D2 as the TSC22D1 sequence used for immunogen is 87% homologous to TSC22D2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TSC22/TSC22D1 Antibody

Western Blot: TSC22/TSC22D1 Antibody [NBP2-24628]

Western Blot: TSC22/TSC22D1 Antibody [NBP2-24628]

Western Blot: TSC22/TSC22D1 Antibody [NBP2-24628] - Analysis of TSC22 in Jurkat cell lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW cell lysate using this antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for TSC22/TSC22D1 Antibody

Application
Recommended Usage

Western Blot

3-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TSC22

Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptionalregulator to modulate cell growth and differentiation and cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in the TGF-beta pathway, and also the PPARgamma signalling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, such as brain and salivary gland tumors, imply an antiproliferative role for TSC-22.

Long Name

TSC22 Domain Family, Member 1

Alternate Names

Egr5, TGFB1I4, TSC22D1

Gene Symbol

TSC22D1

Additional TSC22 Products

Product Documents for TSC22/TSC22D1 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for TSC22/TSC22D1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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