TSH beta Antibody (TSH-116) - BSA Free

Novus Biologicals | Catalog # NB500-363

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Radioimmunoassay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # TSH-116

Format

BSA Free
View all TSH beta Primary Antibodies »

Product Specifications

Immunogen

Human thyrotropin.

Specificity

This antibody (clone TSH-116) reacts with human thyroid stimulating hormone (hTSH, thyrotropin), a glycoprotein hormone produced by the anterior pituitary gland cells in response to signals from the hypothalamus gland in the brain. The TSH-116 reacts with association constant 1.1 x 1011 l/mol. Following cross-reactivity expressed as binding of labelled hormone (% of total) was determined by solid phase RIA with excess of the antibody TSH-116: hTSH (78.9), hCG (20.3), hLH (23.2), hFSH (29.9).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for TSH beta Antibody (TSH-116) - BSA Free

Application
Recommended Usage

ELISA

1:2000

Radioimmunoassay

1:100-1:2000
Application Notes
The antibody TSH-116 is suitable in combination with the antibody TSH-51 for immunometric assays in the screening of neonatal hypothyroidism.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

Phosphate buffered saline (PBS), pH 7.4

Format

BSA Free

Preservative

15mM Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TSH beta

Thyroid-stimulating hormone (TSH), also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non-covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle-stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.

Long Name

Thyroid-stimulating Hormone Subunit beta

Alternate Names

Thyrotropin beta, TSHB

Entrez Gene IDs

7252 (Human)

Gene Symbol

TSHB

Additional TSH beta Products

Product Documents for TSH beta Antibody (TSH-116) - BSA Free

Certificate of Analysis

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Product Specific Notices for TSH beta Antibody (TSH-116) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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