High affinity, ATP-competitive casein kinase 2 (CK2) inhibitor (IC50
= 0.1 μ
= 40 nM). Displays selectivity for CK2 over JNK3, ROCK1 and MET (no inhibitory effects at 10 μ
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Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2.
Golub et al.