Catalog # Availability Size / Price Qty
Tunicamycin | CAS No. 11089-65-9 | Other Transferase Inhibitors
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Description: Antibiotic; GlcNAc phosphotransferase inhibitor

Chemical Name: Tunicamycin from Streptomyces sp.

Product Details
Citations (8)
Reviews (4)

Biological Activity

Tunicamycin is an antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:
  • Homolog A, n=8, C37H60N4O16, molecular weight = 816.90
  • Homolog B, n=9, C38H62N4O16, molecular weight = 830.93
  • Homolog C, n=10, C39H64N4O16, molecular weight = 844.95
  • Homolog D, n=11, C40H66N4O16, molecular weight = 858.99
The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.

Technical Data

C39H64N4O16 (tunicamycin C, n=10)
Soluble to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reviews for Tunicamycin

Average Rating: 4.8 (Based on 4 Reviews)

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Good product
By P Kumar on 04/19/2021
Application: Species: Human

examine effect in AC16 cell line.

Usage Information
By Anonymous on 06/20/2020
Application: Species: Human

5 μg/ml

PMID: 31453810 Reference

Worked at once
By Bibha Dahal on 01/08/2020
Application: Species: Human

I dissolved tunicamycin in DMSO. I added tunicamycin at various concentrations (2uM, 4uM, 6uM, and 10uM) for 24 hours in human primary astrocytes and incubated at 37 C and 5% CO2. Next day, I collected lystates and ran a western blot. The first four lanes are tunicamycin added samples in increasing concentration and the last two lanes are without added. I looked for PERK activation using p-PERK antibody.

Tunicamycin Usage Information
By Chao Li on 01/08/2018
Application: Species: Human

It is working well and easily dissolved into DMSO. I used 2.5, 5 µg/ml of Tunicamycin with serum free culture medium to treat the cells for 8h, 16h, 24h, and 48h.

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