Tunicamycin

  ( 2 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:3516
Chemical Name:Tunicamycin from Streptomyces sp.
Product Details
Citations (2)
Reviews
Biological Activity
Antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:
  • Homolog A, n=8, C37H60N4O16, molecular weight = 816.90
  • Homolog B, n=9, C38H62N4O16, molecular weight = 830.93
  • Homolog C, n=10, C39H64N4O16, molecular weight = 844.95
  • Homolog D, n=11, C40H66N4O16, molecular weight = 858.99
The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.
Technical Data
  • M.Wt:
    844.95
  • Formula:
    C39H64N4O16 (tunicamycin C, n=10)
  • Solubility:
    Soluble to 50 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    11089-65-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tunicamycin include:

2 Citations: Showing 1 - 2
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  1. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.
    Authors: Gupta Et al.
    Oncogene  2016;35:5860
  2. ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.
    Authors: Deldicque Et al.
    PLoS One  2011;6:e20993

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Average Rating: 5 (Based on 1 review)

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  Human Chao Li 01/08/2018
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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