Tunicamycin

Catalog # Availability Size / Price Qty
3516/10
Tunicamycin | CAS No. 11089-65-9 | Other Transferase Inhibitors
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Description: Antibiotic; GlcNAc phosphotransferase inhibitor

Chemical Name: Tunicamycin from Streptomyces sp.

Product Details
Citations (8)
Reviews (1)

Biological Activity

Antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:
  • Homolog A, n=8, C37H60N4O16, molecular weight = 816.90
  • Homolog B, n=9, C38H62N4O16, molecular weight = 830.93
  • Homolog C, n=10, C39H64N4O16, molecular weight = 844.95
  • Homolog D, n=11, C40H66N4O16, molecular weight = 858.99
The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.

Technical Data

M.Wt:
844.95
Formula:
C39H64N4O16 (tunicamycin C, n=10)
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at +4°C
CAS No:
11089-65-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Tunicamycin Usage Information
By Chao Li on 01/08/2018
Species: Human

It is working well and easily dissolved into DMSO. I used 2.5, 5 µg/ml of Tunicamycin with serum free culture medium to treat the cells for 8h, 16h, 24h, and 48h.


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