Catalog Number: 3516
Chemical Name: Tunicamycin from Streptomyces sp.
Biological Activity
Antibiotic; inhibits GlcNAc phosphotransferase (GPT). Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. Activity induces ER stress and causes G1 arrest; can be used to induce autophagy. Tunicamycin contains four main components as follows:
  • Homolog A, n=8, C37H60N4O16, molecular weight = 816.90
  • Homolog B, n=9, C38H62N4O16, molecular weight = 830.93
  • Homolog C, n=10, C39H64N4O16, molecular weight = 844.95
  • Homolog D, n=11, C40H66N4O16, molecular weight = 858.99
The composition of this product will vary from batch to batch and can be found on the relevant certificate of analysis.
Technical Data
  • M.Wt:
    844.95
  • Formula:
    C39H64N4O16 (tunicamycin C, n=10)
  • Solubility:
    Soluble to 50 mM in DMSO
  • Storage:
    Store at +4°C
  • CAS No:
    11089-65-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Primary murine airway smooth muscle cells exposed to poly(I:C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix.
    Lauer et al.
    J.Biol.Chem., 2009;284:5299
  2. Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.
    Ding et al.
    J.Biol.Chem., 2007;282:4702
  3. The hepatitis B virus precore protein is retrotransported from endoplasmic reticulum (ER) to cytosol through the ER-associated pathway.
    Duriez et al.
    J.Biol.Chem., 2008;283:32352
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Tunicamycin include:

1 Citations: Showing 1 - 1

  1. ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.
    Authors: Deldicque Et al.
    PLoS One 2011;6:e20993

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