UA 62784

Key Product Details

Product Description

UA 62784 is an inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.

Product Specifications for UA 62784

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for UA 62784

The following data is based on the product molecular weight 353.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.32 mL	56.60 mL	113.20 mL
1.25 mM	2.26 mL	11.32 mL	22.64 mL
2.5 mM	1.13 mL	5.66 mL	11.32 mL
12.5 mM	0.23 mL	1.13 mL	2.26 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Maiato and Logarinho Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784. Chem.Biol. 2011 PMID: 21700202
• Tcherniuk UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E. Chem.Biol. 2011 PMID: 21609844

Product Documents for UA 62784