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UA 62784

4286 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4286/10
4286/50
UA 62784 | CAS No. 313367-92-9 | Microtubule Binding Compounds
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Description: Inhibits microtubule polymerization

Chemical Name: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one

Purity: ≥99%

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Biological Activity

UA 62784 is an inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.

Technical Data

M.Wt:
353.37
Formula:
C23H15NO3
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
313367-92-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E.
    Tcherniuk et al.
    Chem.Biol., 2011;18:631
  2. Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784.
    Maiato and Logarinho et al.
    Chem.Biol., 2011;18:679

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