Catalog Number: 4286
Chemical Name: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-fluoren-9-one
Biological Activity
Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine (Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.
Technical Data
  • M.Wt:
    353.37
  • Formula:
    C23H15NO3
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    313367-92-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E.
    Tcherniuk et al.
    Chem.Biol., 2011;18:631
  2. Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784.
    Maiato and Logarinho et al.
    Chem.Biol., 2011;18:679

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