Inhibitor of microtubule polymerization in vitro
. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine
(Cat. No. 1256) in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.
Soluble to 25 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
UA62784 is a cytotoxic inhibitor of microtubules, not CENP-E.
Tcherniuk et al.
Motor-dependent and -independent roles of CENP-E at kinetochores: the cautionary tale of UA62784.
Maiato and Logarinho et al.