Chemical Name: Vincaleukoblastine
Biological ActivityVinblastine sulfate is a anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.
Jordan et al.
Cancer Res., 1985;45:2741
The chemotherapeutic agent PacT. inhibits autophagy through two distinct mechanisms that regulate apoptosis.
Veldhoen et al.
Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly.
Rai and Wolf
Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes.
Tsukidate et al.
Citations for Vinblastine sulfate
The citations listed below are publications that use Tocris products. Selected citations for Vinblastine sulfate include:
6 Citations: Showing 1 - 6
Nanoscale Surveillance of the Brain by Microglia via cAMP-Regulated Filopodia.
Authors: Bernier Et al.
Cell Rep 2019;27:2895
The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes PacT. Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
Mol Cancer Ther 2017;16(6):1021
The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated PacT. resistance: a preclinical and pharmacokinetic study.
Authors: Kathawala Et al.
Masitinib antagonizes ATP-binding cassette subfamily C member 10-mediated PacT. resistance: a preclinical study.
Authors: Kathawala Et al.
Mol Cancer Ther 2014;13:714
Characteristics and requirements of basal autophagy in HEK 293 cells.
Authors: Musiwaro Et al.
BMC Cancer 2013;9:1407
Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but Induces the Proliferation of Normal Peripheral Blood Mononuclear Cells.
Authors: Ahmad Et al.
Trop Life Sci Res 2010;21:101
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