Catalog Number: 1256
Chemical Name: Vincaleukoblastine
Biological Activity
Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.
Technical Data
  • M.Wt:
    909.06
  • Formula:
    C46H58N4O9.H2SO4
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    143-67-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.
    Jordan et al.
    Cancer Res., 1985;45:2741
  2. Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes.
    Tsukidate et al.
    Am.J.Pathol., 1993;143:918
  3. Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly.
    Rai and Wolf
    J.Biol.Chem., 1998;273:31131
  4. The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis.
    Veldhoen et al.
    Oncogene, 2012;32:736
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Vinblastine sulfate include:

3 Citations: Showing 1 - 3
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  1. The BTK Inhibitor, Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1 and ABCC10 Overexpressing Cells and Tumors.
    Authors: Zhang
    Mol Cancer Ther 2017;16(6):1021
  2. Characteristics and requirements of basal autophagy in HEK 293 cells.
    Authors: Musiwaro Et al.
    BMC Cancer 2013;9:1407
  3. Catharanthus roseus Aqueous Extract is Cytotoxic to Jurkat Leukaemic T-cells but Induces the Proliferation of Normal Peripheral Blood Mononuclear Cells.
    Authors: Ahmad Et al.
    Trop Life Sci Res 2010;21:101

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