Anticancer agent; microtubule disrupter. Induces apoptosis in cultured hepatocytes and human lymphoma cells. Shown to inhibit autophagosome maturation.
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Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro.
Jordan et al.
Cancer Res., 1985;45:2741
Microtubule antagonists activate programmed cell death (apoptosis) in cultured rat hepatocytes.
Tsukidate et al.
Localization of critical histidyl residues required for vinblastine-induced tubulin polymerization and for microtubulin assembly.
Rai and Wolf
The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis.
Veldhoen et al.
The citations listed below are publications that use Tocris products. Selected citations for Vinblastine sulfate include:
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