UBP 310

  ( 2 citations )    
Product Datasheet
Catalog Number:3621
Chemical Name:(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
Product Details
Citations (2)
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Biological Activity
GLUK5 kainate receptor antagonist (IC50 = 130 nM); also blocks recombinant homomeric GLUK7 receptors. Displays 12,700-fold selectivity for GLUK5 over GLUK6. Exhibits no activity at mGlu group I or NMDA receptors at concentrations of up to 10 μM. Apparent KD value is 18 ± 4 nM for depression of kainate responses on the dorsal root.
Technical Data
  • M.Wt:
    353.35
  • Formula:
    C14H15N3O6S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    902464-46-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for UBP 310 include:

2 Citations: Showing 1 - 2
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  1. A synaptic signature for ON- and OFF-center parasol ganglion cells of the primate retina.
    Authors: Crook Et al.
    Vis Neurosci  2014;31:57
  2. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell.
    Authors: Buldyrev Et al.
    J Neurophysiol  2012;107:1795

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