IAP inhibitor (IC50
values from 0.7 - 3.4 μ
M); inhibits cell growth in multiple cancer cell lines and in a melanoma xenograft model in vivo
. Also suppresses X-linked inhibitor of apoptosis protein (XIAP) and survivin levels. Inhibits the growth of P-glycoproteins and activates caspase-3/7 and caspase-9.
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All Tocris products are intended for laboratory research use only.
Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors.