Highly potent, non-peptidic blocker of the apamin-sensitive Ca2+
= 3 nM in rat sympathetic neurons). Blocks hKCa
2.1 and rKCa
2.2 channels expressed in HEK 293 cells with IC50
values of 762 and 364 pM respectively.
Soluble to 10 mM in DMSO
Desiccate at RT
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Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel.
Campos Rosa et al.
Compounds that block intermediate-conductance (IKCa) and small-conductance (SKCa) calcium-activated potassium channels.
Malik-Hall et al.
Pharmacological characterization of small-conductance Ca2+-activated K+ channels stably expressed in HEK 293 cells.
Strobaek et al.
The citations listed below are publications that use Tocris products. Selected citations for UCL 1684 include:
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