Chemical Name: 6,12,19,20,25,26-Hexahydro-5,27:13,18:21,24-trietheno-11,7-metheno-7H-dibenzo [b,n] [1,5,12,16]tetraazacyclotricosine-5,13-diium dibromide
Biological ActivityUCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons). Blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel.
Campos Rosa et al.
Compounds that block intermediate-conductance (IKCa) and small-conductance (SKCa) calcium-activated potassium channels.
Malik-Hall et al.
Pharmacological characterization of small-conductance Ca2+-activated K+ channels stably expressed in HEK 293 cells.
Strobaek et al.
Citations for UCL 1684
The citations listed below are publications that use Tocris products. Selected citations for UCL 1684 include:
13 Citations: Showing 1 - 10
Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines.
Authors: Abdulkareem Et al.
Heart Rhythm 2016;173:177
5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
Authors: Chien and Su
J Biol Chem 2015;22:42
New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.
Authors: Coleman Et al.
Mol Pharmacol 2014;86:342
Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.
Authors: Kurahashi Et al.
Am J Physiol Cell Physiol 2014;307:C561
Synaptic NMDA receptor-dependent Ca2+ entry drives membrane potential and Ca2+ oscillations in spinal ventral horn neurons.
Authors: Alpert and Alford
PLoS One 2013;8:e63154
Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium.
Authors: Hsueh Et al.
J Biomed Sci 2013;10:891
Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata.
Authors: Benton Et al.
J Neurophysiol 2013;109:2528
Dynamic interplay of excitatory and inhibitory coupling modes of neuronal L-type calcium channels.
Authors: Geier Et al.
Am J Physiol Cell Physiol 2011;300:C937
Twenty-four-hour exposure to altered blood flow modifies endothelial Ca2+-activated K+ channels in rat mesenteric arteries.
Authors: Hilgers Et al.
J Pharmacol Exp Ther 2010;333:210
Allosteric block of KCa2 channels by apamin.
Authors: Lamy Et al.
PLoS One 2010;285:27067
Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in PilC-treated epileptic rats.
Authors: Oliveira Et al.
Brain Res 2010;1348:187
Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats.
Authors: Giachini Et al.
Transl Res 2009;154:183
Glucose stimulates Ca2+ influx and Ins secretion in 2-week-old β-cells lacking ATP-sensitive K+ channels.
Authors: Szollosi Et al.
Br J Pharmacol 2007;282:1747
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